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3.D.4.8.1
Cytochrome oxidase (Cox).  The factors limiting the allotopic production of the Cox2 subunit of yeast cytochrome c oxidase have been discovered (Nieto-Panqueva et al. 2024). The biogenesis pathway followed by the allotopically produced Cox2 subunit based on the participation of the 2 different structural/functional forms of the TIM23 translocon, TIM23MOTOR and TIM23SORT must follow a concerted and sequential mode of action to insert Cox2W56R into the inner mitochondrial membrane in the correct Nout-Cout topology (Nieto-Panqueva et al. 2024). The Plasmodium falciparum putative SURF1 protein can functionally replace SHY1, a COX assembly factor of complex IV of the mitochondrial electron transfer complex of Saccharomyces cerevisiae (Chellappan et al. 2021). 

Accession Number:Q01519
Protein Name:Cytochrome c oxidase subunit 6B
Length:83
Molecular Weight:9788.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Location1 / Topology2 / Orientation3: Mitochondrion1
Substrate

Cross database links:

DIP: DIP-4520N DIP-4520N
Entrez Gene ID: 850727   
Pfam: PF02297   
KEGG: sce:YLR038C   

Gene Ontology

GO:0005751 C:mitochondrial respiratory chain complex IV
GO:0004129 F:cytochrome-c oxidase activity
GO:0033617 P:mitochondrial respiratory chain complex IV assembly

References (7)

[1] “Isolation and characterization of COX12, the nuclear gene for a previously unrecognized subunit of Saccharomyces cerevisiae cytochrome c oxidase.”  Lamarche A.E.et.al.   1331057
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.”  Johnston M.et.al.   9169871
[3] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[4] “Purification of yeast cytochrome c oxidase with a subunit composition resembling the mammalian enzyme.”  Taanman J.-W.et.al.   1331058
[5] “Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method.”  Geier B.M.et.al.   7851399
[6] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[7] “Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.”  Reinders J.et.al.   17761666
Structure:
6GIQ   6HU9   6T0B   6T15   6YMX   6YMY     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MADQENSPLH TVGFDARFPQ QNQTKHCWQS YVDYHKCVNM KGEDFAPCKV FWKTYNALCP 
61:	LDWIEKWDDQ REKGIFAGDI NSD