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3.A.7.2.1 Trw conjugation system of E. coli plasmid IncP. The hexameric form of TrwK is a catalytically active ATPase, much like the structurally related protein TrwB, the conjugative coupling protein (Arechaga et al, 2008), which is a structure-specific DNA-binding protein (Matilla et al., 2010)
Accession Number:	Q04230
Protein Name:	TrwB
Length:	507
Molecular Weight:	56273.00
Species:	Escherichia coli [562]
Number of TMSs:	3
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	protein polypeptide chain

Structure:
DIP:	DIP-16926N
References (9) [1] “Genetic organization of the conjugal DNA processing region of the IncW plasmid R388.” Llosa M.et.al. 8289274 [2] “Functional analysis of unique class II insertion sequence IS1071.” Sota M.et.al. 16391056 [3] “DNA sequence of a plasmid-encoded dihydrofolate reductase.” Swift G.et.al. 7022127 [4] “Site-specific recombination promotes linkage between trimethoprim-and sulfonamide resistance genes. Sequence characterization of dhfrV and sulI and a recombination active locus of Tn21.” Sundstroem L.et.al. 3054482 [5] “Structural and functional analysis of the origin of conjugal transfer of the broad-host-range IncW plasmid R388 and comparison with the related IncN plasmid R46.” Llosa M.et.al. 2038309 [6] “Integrons found in different locations have identical 5' ends but variable 3' ends.” Hall R.M.et.al. 7929000 [7] “TrwD, a protein encoded by the IncW plasmid R388, displays an ATP hydrolase activity essential for bacterial conjugation.” Rivas S.et.al. 9325277 [8] “Characterization and movement of the class 1 integron known as Tn2521 and Tn1405.” Partridge S.R.et.al. 11959558 [9] “The VirB4 family of proposed traffic nucleoside triphosphatases: common motifs in plasmid RP4 TrbE are essential for conjugation and phage adsorption.” Rabel C.et.al. 12533481
1E9R 1E9S 1GKI 1GL6 1GL7

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MHPDDQRKVS AGIVIVLPLI FWITAVQKTE VLGSPKLLAL WELMKLTPQK PILLLSALGG 
61:	LAVGVLFVWL LNSVGQGEFG GAPFKRFLRG TRIVSGGKLK RMTREKAKQV TVAGVPMPRD 
121:	AEPRHLLVNG ATGTGKSVLL RELAYTGLLR GDRMVIVDPN GDMLSKFGRD KDIILNPYDQ 
181:	RTKGWSFFNE IRNDYDWQRY ALSVVPRGKT DEAEEWASYG RLLLRETAKK LALIGTPSMR 
241:	ELFHWTTIAT FDDLRGFLEG TLAESLFAGS NEASKALTSA RFVLSDKLPE HVTMPDGDFS 
301:	IRSWLEDPNG GNLFITWRED MGPALRPLIS AWVDVVCTSI LSLPEEPKRR LWLFIDELAS 
361:	LEKLASLADA LTKGRKAGLR VVAGLQSTSQ LDDVYGVKEA QTLRASFRSL VVLGGSRTDP 
421:	KTNEDMSLSL GEHEVERDRY SKNTGKHHST GRALERVRER VVMPAEIANL PDLTAYVGFA 
481:	GNRPIAKVPL EIKQFANRQP AFVEGTI

3.A.7.2.1
Trw conjugation system of E. coli plasmid IncP. The hexameric form of TrwK is a catalytically active ATPase, much like the structurally related protein TrwB, the conjugative coupling protein (Arechaga et al, 2008), which is a structure-specific DNA-binding protein (Matilla et al., 2010)

Cross database links:

References (9)

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3.A.7.2.1Trw conjugation system of E. coli plasmid IncP. The hexameric form of TrwK is a catalytically active ATPase, much like the structurally related protein TrwB, the conjugative coupling protein (Arechaga et al, 2008), which is a structure-specific DNA-binding protein (Matilla et al., 2010)

Cross database links:

References (9)

External Searches:

Analyze:

3.A.7.2.1
Trw conjugation system of E. coli plasmid IncP. The hexameric form of TrwK is a catalytically active ATPase, much like the structurally related protein TrwB, the conjugative coupling protein (Arechaga et al, 2008), which is a structure-specific DNA-binding protein (Matilla et al., 2010)