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1.C.36.2.1
IIITCP protein complex, YopB/YopD (Olsson et al., 2004). TMS2 is essential for function, while TMS1 is partially defective for translocation, pore formation, and signaling (Ryndak et al. 2005). The system forms a multimeric integral membrane complex (Montagner et al., 2011).  Mutants have been isoated which show defects in effector translocation and pore formation, and many of these are in a C-terminal domain (Solomon et al. 2015).

Accession Number:Q06114
Protein Name:YopB
Length:401
Molecular Weight:41795.00
Species:Yersinia pseudotuberculosis [633]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate protein polypeptide chain

Cross database links:

RefSeq: YP_068464.1   
Entrez Gene ID: 2952948   
BioCyc: YPSE273123:PYV0055-MONOMER   
KEGG: yps:pYV0055   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0009405 P:pathogenesis

References (2)

[1] “YopB and YopD constitute a novel class of Yersinia Yop proteins.”  Haakansson S.et.al.   8418066
[2] “Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis.”  Chain P.S.G.et.al.   15358858

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSALITHDRS TPVTGSLLPY VETPAPAPLQ TQQVAGELKD KNGGVSSQGV QLPAPLAVVA 
61:	SQVTEGQQQE VTKLLESVTR GAAGSQLISN YVSVLTKFTL ASPDTFEIEL GKLVSNLEEV 
121:	RKDIKIADIQ RLHEQNMKKI EENQEKIKET EENAKQVKKS GIASKIFGWL SAIASVIVGA 
181:	IMVASGVGAV AGAMMVASGV IGMANMAVKQ AAEDGLISQE AMKILGPILT AIEVALTVVS 
241:	TVMTFGGSAL KCLANIGAKL GANTASLAAK GAEFSAKVAQ ISTGISNTVG SAVTKLGGSF 
301:	AGLTMSHAIR TGSQATQVAV GVGSGITQTI NNKKQADLQH NNADLALNKA DMAALQSIID 
361:	RLKEELSHLS ESHQQVMELI FQMINAKGDM LHNLAGRPHT V