1.C.36.2.1
IIITCP protein complex, YopB/YopD (Olsson et al., 2004). TMS2 is essential for function, while TMS1 is partially defective for translocation, pore formation, and signaling (Ryndak et al. 2005). The system forms a multimeric integral membrane complex (Montagner et al., 2011). Mutants have been isoated which show defects in effector translocation and pore formation, and many of these are in a C-terminal domain (Solomon et al. 2015).
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| Accession Number: | Q06131 |
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| Protein Name: | YopD |
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| Length: | 306 |
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| Molecular Weight: | 33387.00 |
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| Species: | Yersinia pseudotuberculosis [633] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
protein polypeptide chain |
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1: MTINIKTDSP IITTGSQLDA ITTETVKQSG EIKKTEDTRH EAQAIKSSEA SLSRSQVPEL
61: IKPSQGINVA LLSKSQGDLN GTLSILLLLL ELARKAREMG LQQRDIENKA TITAQKEQVA
121: EMVSGAKLMI AMAVVSGIMA ATSTVASAFS IAKEVKIVKQ EQILNSNIAG REQLIDTKMQ
181: QMSNIGDKAV SREDIGRIWK PEQVADQNKL ALLDKEFRMT DSKANAFNAA TQPLGQMANS
241: AIQVHQGYSQ AEVKEKEVNA SIAANEKQKA EEAMNYNDNF MKDVLRLIEQ YVSSHTHAMK
301: AAFGVV