1.N.1.1.1
The Osteoclast fusion complex including DC-STAMP (470 aas; 7 TMSs), OC-STAMP (566 aas and 7 TMSs) and Leucocyte surface antigen, CD47 of 323 aas and 5 TMSs (Chiu et al. 2016; Møller et al. 2016; Zhang et al. 2014). CD47 is homologous to the first 5 TMSs of Presenilin-1 of Homo sapiens (1.A.54.1.1). It is therefore a presenilin homologue (unpublished observation). Sulforaphene (SFE) downregulates mRNA expression of DC-STAMP, OC-STAMP, and Atp6v0d2, which encode cell-cell fusion molecules (Takagi et al. 2017). SFE attenuates pre-osteoclast multinucleation via suppression of cell-cell fusion. ITIM on DC-STAMP is a functional motif that regulates osteoclast differentiation through the NFATc1/Ca2+ axis (Chiu et al. 2017).
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| Accession Number: | Q08722 |
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| Protein Name: | Leukocyte surface antigen CD47 |
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| Length: | 323 |
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| Molecular Weight: | 35214.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
molecule |
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1: MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN TTEVYVKWKF
61: KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM DKSDAVSHTG NYTCEVTELT
121: REGETIIELK YRVVSWFSPN ENILIVIFPI FAILLFWGQF GIKTLKYRSG GMDEKTIALL
181: VAGLVITVIV IVGAILFVPG EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA
241: ILVIQVIAYI LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ
301: PPRKAVEEPL NAFKESKGMM NDE