2.A.6.3.10
Multidrug resistance pump, CmeDEF. The substrates of CmeDEF include ampicillin, ethidium bromide,
acridine, sodium dodecyl sulfate (SDS), deoxycholate, triclosan, and
cetrimide, but not ciprofloxacin or erythromycin (Pumbwe et al. 2005). This system is similar to the Helicobacter pylori MDR pump, HefABC (Huang et al. 2015).
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| Accession Number: | Q0P9L9 |
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| Protein Name: | Integral membrane component of efflux system (Multidrug efflux system CmeDEF) |
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| Length: | 1005 |
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| Molecular Weight: | 111685.00 |
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| Species: | Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) [192222] |
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| Number of TMSs: | 12 |
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| Substrate |
ampicillin, triclosan, ethidium bromide, sodium dodecyl sulfate, deoxycholate, acridine, Cetrimide |
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1: MFKLAINRPI TVLMFFLALM IFGLISAFSM SVNLFPNVSI PLIKITSKIN GDLNFVESKV
61: TKEIENALSE IDGVKTITSA AYDNFSVSVV EFKLGKNLEV AANDVRDKIG TLSLPSKPEI
121: EKISSDSGSA ISLFLYSKDK LQLMREINDK IKPFLQRVEG VGKIEAKGFL EPQIRIELKP
181: NQLRKYNLNA LDVANIIKSQ NFKQALGELN NNQDNYIIKG YFEATNLEEL SNLRIKTGVF
241: LSDIANISSL YEDEKQSALY EGKEGVLLEL GKITNYNTLE MIKNVKNALP ILEKQIPKDI
301: SINMLYDKSL NIHKHLSQVI FDMVLGIFLT LVIVFLFLRN LSTTLIACIA IPTSIISTFF
361: IIDLLGYDLN RLTFIALTLS IGIFIDDAIV VIENIAKKLK TYPPLQAAFL GINEIGFSVL
421: SISIVLLCVF IPISYMNSIS GLFFNALGIS VASGIVISFL VSVFLIPSIG ARFLNPKENK
481: FYEKTEAFFE KIEQKYENLL YKILQNKVKF ILATLVFIGL SFALATRIGL DFLPMEDDSE
541: IQVLLESKKD LSLEAMKEKS LNLLEKIKND SNVKYAFLLV GYDDAKDATK AKIYVKLKNL
601: DERNLRQSAI VSLYRQKFQD ESLKIKILEL PKIEGAGIDD PVQFLILGDD LNTLKEAASQ
661: AKEILGTNAR IVDISDNANA TKDEVALHIN KEKAKLLDVN PQYIAGVLGY SFSQLSVGSM
721: DRGNSKDDII LSFAPEFKKD IEALKRISIK NNQGINLELS SVVDFIYSKD LKTINRYNKN
781: RSVKITAGVN DLSLGAVQKL LLDNMDKILN NNPSLSYAFS GFINLLGETV QGFAMAVALA
841: FVLIYLVLAA LYESFILPLI IMITMPLAFG GASIGLFITG HNFSLFVLIA IILLFGMVGK
901: NAILLVDVAN KKCHEGLDPD KALLIAGKSR LRAILMTTFA MIFAMLPLAL SRGAGYEANS
961: PMAIAIIFGL ISSTLLTLLV VPALFKFCFK LDSKLRKIYE REKLN