2.A.6.3.10
Multidrug resistance pump, CmeDEF. The substrates of CmeDEF include ampicillin, ethidium bromide,
acridine, sodium dodecyl sulfate (SDS), deoxycholate, triclosan, and
cetrimide, but not ciprofloxacin or erythromycin (Pumbwe et al. 2005). This system is similar to the Helicobacter pylori MDR pump, HefABC (Huang et al. 2015).
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| Accession Number: | Q0P9M0 |
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| Protein Name: | Membrane fusion component of efflux system (Mutlidrug efflux system CmeDEF) |
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| Length: | 246 |
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| Molecular Weight: | 27778.00 |
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| Species: | Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) [192222] |
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| Substrate |
ampicillin, triclosan, ethidium bromide, sodium dodecyl sulfate, deoxycholate, acridine, Cetrimide |
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1: MKKILFLLLV FNCAFGEEIY ASFNVEASKQ SKLALESIGL VQKIPVEIGQ KVSKGELLLA
61: LDQESEKIAL QNAQNSYQLA LVEYENTKSR MQKIKAVENV IDKQSYEDMK AKFDAANLNL
121: NKAKINIAYY KNIMAKKELR APYDAIIANK FIQVGEGVGG VAQPLIEIFS YPQSKLILSF
181: DEKYKDKVRL GDDFFYKIDQ NGTELKGKIN LIYPSIEVKT RKIYAEVQTT NLTPGLFGEG
241: RIITKD