2.A.6.3.10
Multidrug resistance pump, CmeDEF. The substrates of CmeDEF include ampicillin, ethidium bromide,
acridine, sodium dodecyl sulfate (SDS), deoxycholate, triclosan, and
cetrimide, but not ciprofloxacin or erythromycin (Pumbwe et al. 2005). This system is similar to the Helicobacter pylori MDR pump, HefABC (Huang et al. 2015).
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| Accession Number: | Q0P9M1 |
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| Protein Name: | Outer membrane component of efflux system (Multidrug efflux system CmeDEF) |
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| Length: | 424 |
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| Molecular Weight: | 48971.00 |
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| Species: | Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) [192222] |
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| Number of TMSs: | 1 |
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| Substrate |
ampicillin, triclosan, ethidium bromide, sodium dodecyl sulfate, deoxycholate, acridine, Cetrimide |
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1: MFEKYLKSAI FLALYPLAML ASNLHEFIAL SQNNESYLIK QMQSEQANLD KEQAFRNYLP
61: SLSLNSAYVA NNKDRFIIDP QESLFAKVSL NFLLFDGGAR EANLRALESR EKLSLLDKEQ
121: NKNYLALNAI TLYFNTLSLE KILLANQQKV SFLKSTFERL QKFYDAGLSP KDELESIKAK
181: YHLSLLELSQ NELKLANIQK EIKILSDTDF KVQGNAFLEN PQQEKSQNYE VMIAKEQINL
241: AKESVNLAKA EYFPKFYIQD NFNFYKNNYN PKVPAPFANL ADQFLEKYSQ GNQFILGMEW
301: KIFDFNARAK EVEKERLNVQ IANANARFSE RKNKEELNYL DKSLKVLQEQ ILALNLSLNA
361: ANLAFESVDK KYQAGLVSYV EYLQALEVKF KAQSDLELAK NEFEITKANY YFNAGIDLNS
421: KVKE