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2.A.1.8.11
The 24 TMS, 2 domain, NarK1-NarK2 porter (NarK1 = a NO3-/H+ symporter; NarK2 = a NO3-/NO2- antiporter).  NarK1 is a nitrate/proton symporter with high affinity for nitrate while NarK2 is a nitrate/nitrite antiporter with lower affinity for nitrate (Goddard et al., 2008).  Each transporter requires two conserved arginine residues for activity.  A transporter consisting of inactivated NarK1 fused to active NarK2 has a dramatically increased affinity for nitrate compared with NarK2 alone, implying a functional interaction between the two domains (Goddard et al., 2008).

Accession Number:Q166T6
Protein Name:Nitrite extrusion protein
Length:466
Molecular Weight:50452.00
Species:Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp. (strain OCh 114)) [375451]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate nitrite, nitrate

Cross database links:

RefSeq: YP_682693.1   
Entrez Gene ID: 4196310   
Pfam: PF07690   
BioCyc: RDEN375451:RD1_2441-MONOMER   
KEGG: rde:RD1_2441   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015103 F:inorganic anion transmembrane transporter a...
GO:0015698 P:inorganic anion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “The complete genome sequence of Roseobacter denitrificans reveals a mixotrophic rather than photosynthetic metabolism.”  Swingley W.D.et.al.   17098896

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MAITDTSNGS SRHVLTDWRP EDPQFWEEKG KAIATRNLWI SIPNLLMAFS VWMVWSVVVA 
61:	KMPAIGFDFS VSERFWLAAL PGLSGATLRI FYSFVIPVFG GRRWTAISTA SLLLPALGIG 
121:	FAVQNPETSY FTFLILALMC GFGGGNFASS MANIAYFYPK KVKGQALAMN AGLGNLGVSV 
181:	MQFLVPVVIT MGVFGAVGGE PQTLSDGGQL FIQNAGFIWV PFLAIGAIAA WFGMNDIADA 
241:	KASVGEQMSI LGRYHNWVMC VLYVGTFGSF IGYAAGFPLL MKTQFPEVDV LKYAFLGPLV 
301:	GALSRSATGW ISDKFGGGKV TFWVFLGMIV AVYGVITFLP STPEAADGSF WGFFACFMAL 
361:	FFLTGVGNAS TFQMIPSIMK QEIPRLMPNL EATNMQRTIE RESAAIIAFT SAIAAYGAFF 
421:	IPKSYGTSIA ITGSPHGALW AFLGFYAVCT VITWVYYSRK NAPVPC