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1.A.9.1.2
The nicotinic acetylcholine activated cation selective channel precursor, Acr-2 or Acr-3/Unc-38 (both β and α-type chains are required for activity; levamisole-gated; activity reduced by antagonists mecamylamine and d-tubocurarine) (Squire et al., 1995; Baylis et al., 1997). nAChR and TRPC channel proteins (1.A.4) mediate nicotine addiction in many animals from humans to worms (Feng et al., 2006). Functions at synapses in the nervous system and at neuromuscular junctions (Towers et al. 2006). Neonicottinoides affect worm behavior and development (Kudelska et al. 2017). C. elegans has a large number of nAcChR genes, only some of which are retained in parasitic nematodes (Holden-Dye et al. 2013). RIC-3 is an nAcChR chaparone (Treinin 2008).

Accession Number:Q23022
Protein Name:Acetylcholine receptor subunit alpha-type unc-38
Length:511
Molecular Weight:59454.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate cation

Cross database links:

RefSeq: NP_491472.1   
Entrez Gene ID: 172105   
Pfam: PF02931    PF02932   
KEGG: cel:F21F3.5   

Gene Ontology

GO:0030054 C:cell junction
GO:0016021 C:integral to membrane
GO:0045211 C:postsynaptic membrane
GO:0004889 F:nicotinic acetylcholine-activated cation-se...
GO:0004872 F:receptor activity
GO:0006811 P:ion transport

References (2)

[1] “Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits.”  Fleming J.T.et.al.   9221782
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MRSFWLFLLL LLFCISFIKL TEGNEDAKRL YDDLMVNYNR HRRPSTSPNK PLTIKLKLRL 
61:	SQIIDVHEID QIMTCSVWLK QTWIDRKLSW DPVNYGGVNV LYVPYEMIWV PDIVLYNNAD 
121:	SNYNITISTK ATLHYTGEVT WEPPAIFKSM CQIDVRWFPF DEQQCHLKFG SWTFSENLLS 
181:	VELNEPSLRY EEEIDEKGII DNVTVAEDGI DLSDYYPSVE WDIMSRVAKR RAKNYPSCCP 
241:	QSAYIDVTYY LQLRRKPLFY TVNLVFPCVG ISFLTILVFY LPSDSGEKVT LCISILVALT 
301:	IFFLLLTEII PATSITLPLI GKYLLFTMVM VTLSVVVTVI SLNLHFRTPT THLMPNWVKK 
361:	VFLKWLPKLL FMRRPIDDYE EKFDDKKKPK DGKIALSVHA HRVSNVGNNI RNATIDDTIQ 
421:	KMYYSPPVVK AFENICFIAE LLKKKDRDDK IDEDWKYVAM VLDRLFLLIF SIACFVGTVI 
481:	ILLRAPTLYD TRQPIDLQYR PANLSANPIS F