1.A.9.5.6
Gamma-aminobutyric acid receptor, LCCH3 of 496 aas and 4 TMSs/ GRD of 686 aas and 4 TMSs. LCCH3 combines with the ligand-gated ion channel subunit, GRD, to form cation-selective GABA-gated ion channels. The heteromultimeric receptor is activated by GABA (EC50=4.5 microm),
muscimol (EC50=4.8 microm) and trans-4-aminocrotonic acid (EC50=104.5
microm), and partially by cis-4-aminocrotonic acid (EC50=106.3 microm).
Picrotoxin effectively blocked the GABA-gated channel (IC50=0.25 microm), but bicuculline, TPMTA, dieldrin and lindane did
not. The benzodiazepines flunitrazepam and diazepam did not potentiate
the GABA-evoked current (Gisselmann et al. 2004). The system has been partially characterized from the small brown planthopper, Laodelphax striatellus (Fallen), a major
insect pest of crop systems in East Asia (Wei et al. 2017). Isocycloseram is a "GABA-gated chloride channel allosteric modulator (Blythe et al. 2022).
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| Accession Number: | Q24352 |
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| Protein Name: | Gamma-aminobutyric acid receptor alpha-like |
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| Length: | 686 |
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| Molecular Weight: | 76558.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Cell junction1 / Multi-pass membrane protein2 |
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| Substrate |
inorganic cation |
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1: MCTMPATRDA SGSGDASTDL IAARSLSSHQ GQRSNLRIFK LLISCCLLML CIYPNAWPWS
61: IGPGSGPFSV SADSIKGRGD THRLGEMGTS LSSSLPSSWL TQSNNHANIS ELLDNLLRGY
121: DNSIRPDFGG PPATIEVDIM VRSMGPISEV DMTYSMDCYF RQSWVDKRLA FEGAQDTLAL
181: SVSMLARIWK PDTYFYNGKQ SYLHTITTPN KFVRIYQNGR VLYSSRLTIK AGCPMNLADF
241: PMDIQKCPLK FGSFGYTTSD VIYRWNKERP PVAIAEDMKL SQFDLVDCPA GNLTDIVYKA
301: AAPRPQRRPF NNKDPPRPTS KVMTTFAGPA AKNQHVRGTG LKLDKGAFGT GRDATGGSGS
361: TTGLSGTITL ETNHPSEYSM LMVNFHLQRH MGNFLIQVYG PCCLLVVLSW VSFWLNREAT
421: ADRVSLGITT VLTMTFLGLE ARTDLPKVSY PTALDFFVFL SFGFIFATIL QFAVVHYYTK
481: YGSGECYFII EELDSESGES ETEPLTSDFR GSTESKIYEV IPLSMCAISM PPPPTRLGML
541: TSRNRRPRNR RHGLWSMKLL GLFDWRRRRK PPRADSDEDE DDEQTQLRAN EAPTTSAAAA
601: AAQAAAQAAR ISPPTGGRRR MSYYRREEME ARRKGKRTPQ YNSVSKIDRA SRIVFPLLFI
661: LINVFYWYGY LSRSSRILAN TPDAST