2.A.6.2.26
The multidrug efflux pump, VmeAB-VpoC (Matsuo et al., 2007). There are 11 RND-type efflux transporters in Vibrio parahaemolyticus, and several (VmeCD, VmeEF and VmeYZ) contribute not only to intrinsic drug resistance but also to virulence (Matsuo et al. 2013).
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| Accession Number: | Q2AAU3 |
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| Protein Name: | VmeB |
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| Length: | 1053 |
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| Molecular Weight: | 113402.00 |
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| Species: | Vibrio parahaemolyticus [670] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
drug |
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1: MARFFIDRPV FAWVLAILTM LAGIMSLFNL PVSQYPTISP TTITISARYP GASAKTVEDS
61: VTQVIEQNMT GLDYLRYLSS SSDAFGNATI TLTFDSEADP DIAQVQVQNK LQLALTSLPM
121: EVQSQGIVVN KSNTSFLMVV AVYSDDPDFT QNDIADFVVT NIQDPISRVT GVGQVQAFGS
181: QYAMRVWLDP FKLTQFNLTA IDVANAISEQ NAQVSSGQLG AAPAQKGQLL NATISSASRL
241: SSVAEFQNII LKSDASGANV YLRDVARIER GAESYDIQGQ YNGLPASGLG ISLGTGANAL
301: ETAAAVKERL AELSENFPDG LKVAYPFETT PFVEASIQEV VKTLLEAIVL VFLIMYLFLQ
361: NFRATIIPTI AVPVVLLGTF AILYATGFSV NTLTMFAMVL AIGLLVDDAI VVVENVERVM
421: HEDGLDPKEA TKKSMGQITG ALIGVGLTLS AVFVPMAFMS GSTGVIYRQF SITIVAAMTL
481: SVMVAIILTP ALCATLLKKG DAEFTDKKGF FGWFNRKFDS MTAGYEAGVA KLLKRTGRML
541: LVFVAMSAGA GWLFMNLPTS FLPDEDQGTV FSMAILPPNS TQEQTEKTLD KVRSYFLEEE
601: KDNVRSVFTV AGFSFAGQGQ NMGMAFIGLK DWSEREAPGS DAASLTGRAM GYFSTIKEAM
661: VFAFAPPAIQ ELGNATGFDF YLQDSLSLGH EALVAAQGQL LGMAAQNPKL VGVRPNGQSD
721: APMYQVHVDH VKLRALDVSI NDVNQILSAA WGGAYINDYI DRGRVKKVMV QSDAEFRMQP
781: EDFNSWYVRN AQGEMVPFSA FASGEWTYGS PQLQRFNGLA AMNIQGGAAP GVSTGEAMAE
841: IEAMVEQLPE GFTVNWNGIS YEERLSGNQA PMLYALSILV VFLVLAALYE SWSVPLAVVL
901: VVPLGVLGAV LAVLGRGMDN DVFFQVSLLT TVGLATKNAI LIVEFAKEYY EKGAGLIEAT
961: LHAVRVRLRP IIMTSLAFGL GVVPLAISAG VGSAGQNAVG TGVLGGMISA TLLGIFFVPV
1021: FFVVVERLFD RRAQKEAQKE RSQELDPATE KSE