2.A.6.2.44
Multidrug efflux pump, AdeFGH. Mediates high level resistance to chloramphenicol, clindamycin, fluoroquinolones, carbapenem and
trimethoprim and decreased susceptibility to tetracycline-tigecycline
and sulfonamides;
susceptibility to β-lactams, erythromycin, aminoglycosides and rifampin was not
affected. It also mediates increased resistance to ethidium bromide,
safranin O, acridine orange, trimethoprim and
sulfamethoxazole (Coyne et al. 2010; AlQumaizi et al. 2022).
|
| Accession Number: | Q2FD80 |
|---|
| Protein Name: | Putative RND family drug transporter |
|---|
| Length: | 483 |
|---|
| Molecular Weight: | 52465.00 |
|---|
| Species: | Acinetobacter baumannii [470] |
|---|
| Number of TMSs: | 1 |
|---|
| Substrate |
fluoroquinolone antibiotic, trimethoprim, chloramphenicol, safranin O, ethidium bromide, acridine orange free base, clindamycin, sulfanilamide, sulfamethoxazole |
|---|
1: MVITSKQNWL LSSLMGSLLL AGCSLAPEYQ PAKVIVPVKF KESDPKLEDN NWKIAQPADQ
61: QTRGEWWRIY NDAQLNELEQ QAIAGNQNLK AVAANIQASR ALRSAAQAER LPSIDAGFGP
121: TRQKPSPASL GLDDNAHTSA QTLWRAQANV SYELDLFGRV ASSVNAATAD LQQQEALYQS
181: ALLALQADVA QGYFLIRQLD TEQAIYNRTI KLLGETRDLM QLRFKNGLVS ELDVSRAQTE
241: LATAQTTALN IARNRASAEH ALAVLLGKPP ADFNLAVQPL TANSIRLPAG LPSTLLERRP
301: DIAAAERAMA ADNARIGIAR AAFFPKLSLT GALGYESSSL SELGKWSSRT FLLGPVAGTI
361: LSLPLFDGGQ RKAGVAQARA AYEESVANYR QTVLNAFREV ENGLSDQRIL DQQIQAQNQA
421: LSSSRHANQL SHLRYREGAI SYLDVIDSDR TILQQEQLAA QLKGSQIIAS INLIRALGGG
481: WSS