1.A.77.1.7 Mitochondrial Ca2+ Uniporter, a channel complex. MCU is a putative 5TMS protein (307 aas) with homology to MCU Ca2+/Mg2+ channels in the C-terminal 2TMS domain. The N-terminal domain is found only in Trypanosoma and Leishmania species. The TbMCU complex possesses four subunits, MCU (307 aas), MCUb (214 aas), MCUc (254 aas) and MCUd (249 aas)), present only in trypanosomatids and required for Ca2+ transport.
These four subunits interact
through their transmembrane helices to form hetero-oligomers in a ~380 KDa complex (Huang and Docampo 2018).
|
Accession Number: | Q387B7 |
Protein Name: | Uncharacterized protein |
Length: | 307 |
Molecular Weight: | 34885.00 |
Species: | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) [185431] |
Number of TMSs: | 3 |
Substrate |
calcium(2+), magnesium(2+) |
---|
1: MWRPYTLFVV PMRFGSPLQL RSLFVSRMPG RFDAFLTRRF VSTATPGGQP ICSDSHNSAA
61: CLTAEEFSNI VPMFLLGQAL RQHTSNEENR AGAGEFVITR EVFNRYCSES HVEDTDKALQ
121: LLCESGVVVS ISDGAAVHLR PVQFLQMHND AADASDAKVK TPFEDYIRAA QNRLADAEAE
181: EMAMRVALQP AIDNAAKRRR LLWSGALCLM AVQLAVISRL TFVDLDWDIM EPVSYFLGSG
241: TSILFLIYLL RNGRVKSYKE YEEKAAASRV RLHAPADFEW RKYDAVVRRV EVEKNMVEQM
301: RKWFKHH