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3.A.20.1.3
Glycosomal membrane protein insertion apparatus.  Two proteins included in the system are PEX14 and PEX19 which target to the peroxisome in several other organisms, but in T. brucei, they target to the glycosome.  By contrast, PEX10 and PEX12 are involved in targetting to the peroxisome (Saveria et al. 2007). Altogether, PEX1, 2, 5, 6, 10, 11, 12, 14, 16, and 19 have been identified in T. brucei and are listed here. Inhibitors of PEX14 block protein import into glycosomes and kill Trypanosma parasites (Dawidowski et al. 2017). The glycosomal membrane-associated Leishmania donovani protein PEX14, which plays a crucial role in protein import from the cytosol to the glycosomal matrix, consists of three domains: an N-terminal domain where the signalling molecule binds, a transmembrane domain and an 84-residue coiled-coil domain (CC) that is responsible for oligomerization. CCs are versatile domains that participate in a variety of functions including supramolecular assembly, cellular signalling and transport (Shakya and Pratap 2020).

Accession Number:Q38CL4
Protein Name:Peroxin 14, putative
Length:366
Molecular Weight:39937.00
Species:Trypanosoma brucei brucei (strain 927/4 GUTat10.1) [185431]
Substrate protein polypeptide chain

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FASTA formatted sequence
1:	MSLLLSGVVD DGKSKPEVEH THSEREKRVS NAVEFLLDSR VRRTPTSSKV HFLKSKGLSA 
61:	EEICEAFTKV GQPKTLNEIK RILSERPYVP TGPNSQHMTQ PLRDESADSV PTPHPNQSRR 
121:	HTSLLYAPQA PPLPEAAAAT RGVDWRDLVI GAGAAVIGGF AAFKAFQLYS PYEIRLKDEG 
181:	SKPRSRRSRR GGRHASSDSE AERSLVHREV PALPVPAIPV ASESHVDAKQ AEIERLKTEL 
241:	KETQEALEAE KKGKAELSIT LGKLRGQVTA YSRTNEKQES QIKSLQEEVN RLKSEIERKE 
301:	DSAKVNANSN VEETLDSKEE GLPSSDTESS NPNGASSEVA RDTQQQDGPA PLSTETDGTV 
361:	VGGEAA