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3.A.20.1.3
Glycosomal membrane protein insertion apparatus.  Two proteins included in the system are PEX14 and PEX19 which target to the peroxisome in several other organisms, but in T. brucei, they target to the glycosome.  By contrast, PEX10 and PEX12 are involved in targetting to the peroxisome (Saveria et al. 2007). Altogether, PEX1, 2, 5, 6, 10, 11, 12, 14, 16, and 19 have been identified in T. brucei and are listed here. Inhibitors of PEX14 block protein import into glycosomes and kill Trypanosma parasites (Dawidowski et al. 2017). The glycosomal membrane-associated Leishmania donovani protein PEX14, which plays a crucial role in protein import from the cytosol to the glycosomal matrix, consists of three domains: an N-terminal domain where the signalling molecule binds, a transmembrane domain and an 84-residue coiled-coil domain (CC) that is responsible for oligomerization. CCs are versatile domains that participate in a variety of functions including supramolecular assembly, cellular signalling and transport (Shakya and Pratap 2020).

Accession Number:Q38IE1
Protein Name:PEX6
Length:982
Molecular Weight:106011.00
Species:Trypanosoma brucei [5691]
Number of TMSs:1
Substrate protein polypeptide chain

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMSRTVELER CILRTKTYEA YKNVLQQSTS MTDHAQSLVN TLIQTHGEMH LGEKIPSGDG 
61:	RPVEFVVVDL VPATVGTLTE STTVIVLPPS SDGKELPPTA AMGTTGSSAE GTGADGVSTN 
121:	NELERGGICS VRLDYSLSGS STAASEAFLL STLLQDGSIV CVGDEEYTTA FTLVRQRDDP 
181:	VPTTEQQEQA ETQRRKQQCD TLPTLYASPS VFRNIRAFLM LDVLPTIMKS RFQYNDDQLC 
241:	VPVSLFREVH NGSGAPITIE AVSSGSRKEL HLSAVAVTPA WPVFILTEVF GESYETLLTA 
301:	TLKASERALH GRIVAEGDVI VLSVTPTQLV EMQLEPNTAV EAVLVQVIHA VQSGCALPAV 
361:	VTSVLHDGAI AIPFRVLEVN TLSGAAYGRI ELEDKGNGTE LLLLLQIALG SPDTTPLFPP 
421:	PPTPPTFFPQ LSLTMNIRSA LERCYVPSNA GTTSVFVVHA TKENLPVECV SMVMALLGVE 
481:	CLLVDMERKS DEEVQRLLGA YMSCSGEVAL VIRNATKLDQ RTELLRLFDA DNSGNGVDGT 
541:	CSDGDCLNGI RVIFLVCECV EAPPPAVAAQ ARNVEGVLKG THPSEKDRRL IVENIFTGAQ 
601:	RSRGFCKSLL LSFDSVASWT VGLSTVDVVA YAEECVSVLA SMSLPDGVLP VLSESLCSSI 
661:	LEKFQKAHGH NLVSTKLQPV RWSDVGGLED AKRELREMIQ LPLLYPELLG NGGNAKHGAG 
721:	ILFYGPPGCG KTLLAKAVAT EMNMNFMAVK GPELINQYVG ESEKNIRLLF QRARDNSPCI 
781:	IFFDELDALA PARGAKGDAG GAMDRVVAQL LVEVDGVGHS RSDGTAAGKV FIIAATNRPD 
841:	LLDPALLRPG RFDKLCYLGI PSTRSEQLVA LRALTRKFHL AEDVDLEALL QPMTLDYTGA 
901:	DLFALCSDAM MFAVEAMLQE SLTFNEEGSP SMLAEPAKNL VVRMNDFVRA RDQLKPSVTA 
961:	EDLRRYESLR TKFTANSGRV AD