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1.C.72.3.1 The Subtilase cytotoxin, SubAB. Pentameric SubB, but not SubA, is homologous to ArtB of Salmonella enterica. SubA (AB5 subtilase) cytotoxin inactivates the endoplasmic reticulum chaperone, BiP (Paton et al., 2006; Beddoe et al., 2010).
Accession Number:	Q3ZTX7
Protein Name:	Subtilase cytotoxin, subunit A
Length:	347
Molecular Weight:	37480.00
Species:	Escherichia coli [562]
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	toxin

RefSeq:	YP_308822.1
Entrez Gene ID:	3654564
Pfam:	PF00082
Gene Ontology GO:0004252 F:serine-type endopeptidase activity GO:0006508 P:proteolysis
References (1) [1] “Transfer region of pO113 from enterohemorrhagic Escherichia coli: similarity with R64 and identification of a novel plasmid-encoded autotransporter, EpeA.” Leyton D.L.et.al. 14573650

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CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	MLKILWTYIL FLLFISASAR AEKPWYFDAI GLTETTMSLT DKNTPVVVSV VDSGVAFIGG 
61:	LSDSEFAKFS FTQDGSPFPV KKSEALYIHG TAMASLIASR YGIYGVYPHA LISSRRVIPD 
121:	GVQDSWIRAI ESIMSNVFLA PGEEKIINIS GGQKGVASAS VWTELLSRMG RNNDRLIVAA 
181:	VGNDGADIRK LSAQQRIWPA AYHPVSSVNK KQDPVIRVAA LAQYRKGETP VLHGGGITGS 
241:	RFGNNWVDIA APGQNITFLR PDGKTGTGSG TSEATAIVSG VLAAMTSCNP RATATELKRT 
301:	LLESADKYPS LVDKVTEGRV LNAEKAISMF CKKNYIPVRQ GRMSEEL

1.C.72.3.1
The Subtilase cytotoxin, SubAB. Pentameric SubB, but not SubA, is homologous to ArtB of Salmonella enterica. SubA (AB5 subtilase) cytotoxin inactivates the endoplasmic reticulum chaperone, BiP (Paton et al., 2006; Beddoe et al., 2010).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

1.C.72.3.1The Subtilase cytotoxin, SubAB. Pentameric SubB, but not SubA, is homologous to ArtB of Salmonella enterica. SubA (AB5 subtilase) cytotoxin inactivates the endoplasmic reticulum chaperone, BiP (Paton et al., 2006; Beddoe et al., 2010).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

1.C.72.3.1
The Subtilase cytotoxin, SubAB. Pentameric SubB, but not SubA, is homologous to ArtB of Salmonella enterica. SubA (AB5 subtilase) cytotoxin inactivates the endoplasmic reticulum chaperone, BiP (Paton et al., 2006; Beddoe et al., 2010).