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3.A.7.3.1
Pertussis toxin exporter. For consideration of the requirements for assembly, see Verma and Burns, 2007.

Accession Number:Q45390
Protein Name:PtlA
Length:102
Molecular Weight:10813.00
Species:Bordetella pertussis [520]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

RefSeq: NP_882287.1   
Entrez Gene ID: 2665409   
Pfam: PF04956   
BioCyc: BPER257313:BP3788-MONOMER   
KEGG: bpe:BP3788   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006810 P:transport

References (7)

[1] “Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication.”  Nicosia A.et.al.   2873570
[2] “Molecular characterization of an operon required for pertussis toxin secretion.”  Weiss A.A.et.al.   8464913
[3] “Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.”  Parkhill J.et.al.   12910271
[4] “Synergistic binding of RNA polymerase and BvgA phosphate to the pertussis toxin promoter of Bordetella pertussis.”  Boucher P.E.et.al.   7592424
[5] “The pertussis toxin liberation genes of Bordetella pertussis are transcriptionally linked to the pertussis toxin operon.”  Ricci S.et.al.   8606119
[6] “Mutants in the ptlA-H genes of Bordetella pertussis are deficient for pertussis toxin secretion.”  Craig-Mylius K.A.et.al.   10518754
[7] “Analysis of subassemblies of pertussis toxin subunits in vivo and their interaction with the ptl transport apparatus.”  Burns D.L.et.al.   15322034

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNPLKDLRAS LPRLAFMAAC TLLSATLPDL AQAGGGLQRV NHFMASIVVV LRGASVATVT 
61:	IAIIWAGYKL LFRHADVLDV VRVVLAGLLI GASAEIARYL LT