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1.C.98.1.1
The heterotrimeric CDT, CdtA/B/C toxin complex. CdtA and CdtC may form a heterodimeric complex required for CdtB delivery. Localized to the cell outer membrane. Contains a ricin B-type lectin domain (Smith and Bayles 2006).  All three have an N-terminal TMS, and possibly a second one near their C-termini.

Accession Number:Q46669
Protein Name:Cytolethal distending toxin subunit B
Length:269
Molecular Weight:29529.00
Species:Escherichia coli [562]
Location1 / Topology2 / Orientation3: Secreted1
Substrate molecule

Cross database links:

Pfam: PF03372   

Gene Ontology

GO:0005576 C:extracellular region
GO:0004519 F:endonuclease activity
GO:0009405 P:pathogenesis

References (5)

[1] “Cloning, sequencing, and expression of the Escherichia coli cytolethal distending toxin genes.”  Pickett C.L.et.al.   8112838
[2] “Escherichia coli CdtB mediates cytolethal distending toxin cell cycle arrest.”  Elwell C.A.et.al.   11292766
[3] “DNase I homologous residues in CdtB are critical for cytolethal distending toxin-mediated cell cycle arrest.”  Elwell C.A.et.al.   10972814
[4] “Nuclear localization of the Escherichia coli cytolethal distending toxin CdtB subunit.”  McSweeney L.A.et.al.   15056215
[5] “Differences in crystal and solution structures of the cytolethal distending toxin B subunit: Relevance to nuclear translocation and functional activation.”  Hontz J.S.et.al.   16809347
Structure:
2F1N     

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKYIISLIV FLSFYAQADL TDFRVATWNL QGASATTESK WNINVRQLIS GENAVDILAV 
61:	QEAGSPPSTA VDTGTLIPSP GIPVRELIWN LSTNSRPQQV YIYFSAVDAL GGRVNLALVS 
121:	NRRADEVFVL SPVRQGGRPL LGIRIGNDAF FTAHAIAMRN NDAPALVEEV YNFFRDSRDP 
181:	VHQALNWMIL GDFNREPADL EMNLTVPVRR ASEIISPAAA TQTSQRTLDY AVAGNSVAFR 
241:	PSPLQAGIVY GARRTQISSD HFPVGVSRR