3.A.1.5.41
Oligopeptide transporter, OppABCDF/MppA/YgiS. MppA is a murein peptide receptor, and YgiS is a bile acid (e.g., cholate, deoxycholate) receptor that may use the Opp system for uptake. YgiS mRNA is degraded by the toxin, MgsR, which is regulated by the antitoxin, MgsA, and this loss of the mRNA protects the cell against bile acid stress (Kwan et al. 2015). oppA translation is activated by MicF through a mechanism of
action involving facilitated access to a translation-enhancing region in
oppA 5'UTR. MicF activation of oppA translation depends on cross-regulation by negative trans-acting effectors, the GcvB sRNA and the RNA chaperone protein Hfq (Carrier et al. 2023).
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| Accession Number: | Q46863 |
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| Protein Name: | Probable deoxycholate-binding periplasmic protein YgiS |
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| Length: | 535 |
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| Molecular Weight: | 60694.00 |
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| Species: | Escherichia coli (strain K12) [83333] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Periplasm1 |
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| Substrate |
oligopeptide |
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1: MYTRNLLWLV SLVSAAPLYA ADVPANTPLA PQQVFRYNNH SDPGTLDPQK VEENTAAQIV
61: LDLFEGLVWM DGEGQVQPAQ AERWEILDGG KRYIFHLRSG LQWSDGQPLT AEDFVLGWQR
121: AVDPKTASPF AGYLAQAHIN NAAAIVAGKA DVTSLGVKAT DDRTLEVTLE QPVPWFTTML
181: AWPTLFPVPH HVIAKHGDSW SKPENMVYNG AFVLDQWVVN EKITARKNPK YRDAQHTVLQ
241: QVEYLALDNS VTGYNRYRAG EVDLTWVPAQ QIPAIEKSLP GELRIIPRLN SEYYNFNLEK
301: PPFNDVRVRR ALYLTVDRQL IAQKVLGLRT PATTLTPPEV KGFSATTFDE LQKPMSERVA
361: MAKALLKQAG YDASHPLRFE LFYNKYDLHE KTAIALSSEW KKWLGAQVTL RTMEWKTYLD
421: ARRAGDFMLS RQSWDATYND ASSFLNTLKS DSEENVGHWK NAQYDALLNQ ATQITDATKR
481: NALYQQAEVI INQQAPLIPI YYQPLIKLLK PYVGGFPLHN PQDYVYSKEL YIKAH