3.A.7.12.1
The Cag pathogenicity island (PAI) proteins (Kutter et al., 2008). CagD (Cag24) is essential for CagA translocation and maximal induction of interleukin-8 secretion (Cendron et al., 2009). It is required for a pro-inflammatory response and multiple cytoskeletal and gene regulatory effects in gastric epithelial cells. Its molecular properties are described in a review by Fischer (2011). Cag16 (CagM) (of unknown function and not dermonstrably homologous to proteins of type IV secretion systems in other bacteria) has 3-4 TMSs and is essential for CagA export. It may therefore be a core protein of the Cag complex (Ling et al. 2013).
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| Accession Number: | Q48252 |
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| Protein Name: | Cag23 |
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| Length: | 983 |
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| Molecular Weight: | 112021.00 |
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| Species: | Helicobacter pylori (Campylobacter pylori) [210] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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| DIP: |
DIP-3373N
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| RefSeq: |
NP_207340.1
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| Entrez Gene ID: |
900243
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| Pfam: |
PF03135
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| KEGG: |
hpy:HP0544
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[1] “Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells.” Tummuru M.K.R. et.al. 8825091
[2] “cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors.” Censini S. et.al. 8962108
[3] “The complete genome sequence of the gastric pathogen Helicobacter pylori.” Tomb J.-F. et.al. 9252185
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1: MFVASKQADE QKKLVIEQEV QKRQFKKIEE LKADMQKGVN PFFKVLFDGG NRLFGFPETF
61: IYSSIFILFV TIVLSVILFQ AYEPVLIVAI VIVLVALGFK KDYRLYQRME RAMKFKKPFL
121: FKGVKNKAFM SIFSMKPSKE MANDIHLNPN REDRLVSAAN SYLANNYECF LDDGVILTNN
181: YSLLGTIKLG GIDFLTTSKK DLIELHASIY SVFRNFVTPE FKFYFHTVKK KIVIDETNRD
241: YSLIFSNDFM RAYNEKQKRE SFYDISFYLT IEQDLLDTLN EPVMNKKHFA DNNFEEFQRI
301: IRAKLENFKD RIELIEELLS KYHPIRLKEY TKDGVIYSKQ CEFYNFLVGM NEAPFICNRK
361: DLYLKEKMHG GVKEVYFANK HGKILNDDLS EKYFSAIEIS EYAPKSQSDL FDKINALDSE
421: FIFMHAYSPK NSQVLKDKLA FTSRRIIISG GSKEQGMTLG CLSELVGNGD ITLGSYGNSL
481: VLFADSFEKM KQSVKECVSS LNAKGFLANA ATFSMENYFF AKHCSFITLP FIFDVTSNNF
541: ADFIAMRAMS FDGNQENNAW GNSVMTLKSE INSPFYLNFH MPTDFGSASA GHTLILGSTG
601: SGKTVFMSMT LNAMGQFVHN FPANVSKDKQ KLTMVYMDKD YGAYGNIVAM GGEYVKIELG
661: TDTGLNPFAW AACVQKTNAT MEQKQTAISV VKELVKNLAT KSDEKDENGN SISFSLADSN
721: TLAAAVTNLI TGDMNLDYPI TQLINAFGKD HNDPNGLVAR LAPFCKSTNG EFQWLFDNKA
781: TDRLDFSKTI IGVDGSSFLD NNDVSPFICF YLFARIQEAM DGRRFVLDID EAWKYLGDPK
841: VAYFVRDMLK TARKRNAIVR LATQSITDLL ACPIADTIRE QCPTKIFLRN DGGNLSDYQR
901: LANVTEKEFE IITKGLDRKI LYKQDGSPSV IASFNLRGIP KEYLKILSTD TVFVKEIDKI
961: IQNHSIIDKY QALRQMYQQI KEY