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3.A.3.1.6 Spiny dogfish Na⁺,K⁺-ATPase (3-d structure solved at 2.4 Å resolution, Shinoda et al., 2009). The α-subunit is 88% identical to the human Na⁺,K⁺ATPase (TC# 3.A.3.1.1).
Accession Number:	Q4H132
Protein Name:	Na, K-ATPase alpha subunit
Length:	1028
Molecular Weight:	113191.00
Species:	Squalus acanthias (Spiny dogfish) [7797]
Number of TMSs:	8
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Single-pass membrane protein²
Substrate	sodium(1+), potassium(1+)

Structure:
Pfam:	PF00689 PF00690 PF00122 PF00702
Gene Ontology GO:0016021 C:integral to membrane GO:0005524 F:ATP binding GO:0015662 F:ATPase activity, coupled to transmembrane m... GO:0015077 F:monovalent inorganic cation transmembrane t... GO:0006754 P:ATP biosynthetic process GO:0015672 P:monovalent inorganic cation transport
References (1) [1] “Interaction of FXYD10 (PLMS) with Na,K-ATPase from shark rectal glands. Close proximity of Cys74 of FXYD10 to Cys254 in the a domain of the alpha-subunit revealed by intermolecular thiol cross-linking.” Mahmmoud Y.A.et.al. 15919665
2ZXE 3A3Y 5AVQ 5AVR 5AVS 5AVT 5AVU 5AVV 5AVW 5AVX [...more]

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MGKGTASDKY EPAATSENAT KSKKKGKKDK IDKKRDLDEL KKEVSMDDHK LSLDELHNKY 
61:	GTDLTRGLTN ARAKEILARD GPNSLTPPPT TPEWIKFCRQ LFGGFSILLW IGAILCFLAY 
121:	GIQAATEDEP ANDNLYLGVV LSTVVIVTGC FSYYQEAKSS RIMDSFKNMV PQQALVIRDG 
181:	EKSTINAEFV VAGDLVEVKG GDRIPADLRI ISAHGCKVDN SSLTGESEPQ TRSPEFSSEN 
241:	PLETRNIAFF STNCVEGTAR GVVVYTGDRT VMGRIATLAS GLEVGRTPIA IEIEHFIHII 
301:	TGVAVFLGVS FFILSLILGY SWLEAVIFLI GIIVANVPEG LLATVTVCLT LTAKRMARKN 
361:	CLVKNLEAVE TLGSTSTICS DKTGTLTQNR MTVAHMWFDN QIHEADTTEN QSGAAFDKTS 
421:	ATWSALSRIA ALCNRAVFQA GQDNVPILKR SVAGDASESA LLKCIELCCG SVQGMRDRNP 
481:	KIVEIPFNST NKYQLSIHEN EKSSESRYLL VMKGAPERIL DRCSTILLNG AEEPLKEDMK 
541:	EAFQNAYLEL GGLGERVLGF CHFALPEDKY NEGYPFDADE PNFPTTDLCF VGLMAMIDPP 
601:	RAAVPDAVGK CRSAGIKVIM VTGDHPITAK AIAKGVGIIS EGNETIEDIA ARLNIPIGQV 
661:	NPRDAKACVV HGSDLKDLST EVLDDILHYH TEIVFARTSP QQKLIIVEGC QRQGAIVAVT 
721:	GDGVNDSPAL KKADIGVAMG ISGSDVSKQA ADMILLDDNF ASIVTGVEEG RLIFDNLKKS 
781:	IAYTLTSNIP EITPFLVFII GNVPLPLGTV TILCIDLGTD MVPAISLAYE QAESDIMKRQ 
841:	PRNPKTDKLV NERLISMAYG QIGMIQALGG FFSYFVILAE NGFLPMDLIG KRVRWDDRWI 
901:	SDVEDSFGQQ WTYEQRKIVE FTCHTSFFIS IVVVQWADLI ICKTRRNSIF QQGMKNKILI 
961:	FGLFEETALA AFLSYCPGTD VALRMYPLKP SWWFCAFPYS LIIFLYDEMR RFIIRRSPGG 
1021:	WVEQETYY

3.A.3.1.6
Spiny dogfish Na⁺,K⁺-ATPase (3-d structure solved at 2.4 Å resolution, Shinoda et al., 2009). The α-subunit is 88% identical to the human Na⁺,K⁺ATPase (TC# 3.A.3.1.1).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

3.A.3.1.6Spiny dogfish Na+,K+-ATPase (3-d structure solved at 2.4 Å resolution, Shinoda et al., 2009). The α-subunit is 88% identical to the human Na+,K+ ATPase (TC# 3.A.3.1.1).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

3.A.3.1.6
Spiny dogfish Na⁺,K⁺-ATPase (3-d structure solved at 2.4 Å resolution, Shinoda et al., 2009). The α-subunit is 88% identical to the human Na⁺,K⁺ATPase (TC# 3.A.3.1.1).