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3.A.3.1.6
Spiny dogfish Na+,K+-ATPase (3-d structure solved at 2.4 Å resolution, Shinoda et al., 2009). The α-subunit is 88% identical to the human Na+,K+ ATPase (TC# 3.A.3.1.1).

Accession Number:Q4H132
Protein Name:Na, K-ATPase alpha subunit
Length:1028
Molecular Weight:113191.00
Species:Squalus acanthias (Spiny dogfish) [7797]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass membrane protein2
Substrate Na+, K+

Cross database links:

Pfam: PF00689    PF00690    PF00122    PF00702   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0015662 F:ATPase activity, coupled to transmembrane m...
GO:0015077 F:monovalent inorganic cation transmembrane t...
GO:0006754 P:ATP biosynthetic process
GO:0015672 P:monovalent inorganic cation transport

References (1)

[1] “Interaction of FXYD10 (PLMS) with Na,K-ATPase from shark rectal glands. Close proximity of Cys74 of FXYD10 to Cys254 in the a domain of the alpha-subunit revealed by intermolecular thiol cross-linking.”  Mahmmoud Y.A.et.al.   15919665
Structure:
2ZXE   3A3Y   5AVQ   5AVR   5AVS   5AVT   5AVU   5AVV   5AVW   5AVX   [...more]

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGKGTASDKY EPAATSENAT KSKKKGKKDK IDKKRDLDEL KKEVSMDDHK LSLDELHNKY 
61:	GTDLTRGLTN ARAKEILARD GPNSLTPPPT TPEWIKFCRQ LFGGFSILLW IGAILCFLAY 
121:	GIQAATEDEP ANDNLYLGVV LSTVVIVTGC FSYYQEAKSS RIMDSFKNMV PQQALVIRDG 
181:	EKSTINAEFV VAGDLVEVKG GDRIPADLRI ISAHGCKVDN SSLTGESEPQ TRSPEFSSEN 
241:	PLETRNIAFF STNCVEGTAR GVVVYTGDRT VMGRIATLAS GLEVGRTPIA IEIEHFIHII 
301:	TGVAVFLGVS FFILSLILGY SWLEAVIFLI GIIVANVPEG LLATVTVCLT LTAKRMARKN 
361:	CLVKNLEAVE TLGSTSTICS DKTGTLTQNR MTVAHMWFDN QIHEADTTEN QSGAAFDKTS 
421:	ATWSALSRIA ALCNRAVFQA GQDNVPILKR SVAGDASESA LLKCIELCCG SVQGMRDRNP 
481:	KIVEIPFNST NKYQLSIHEN EKSSESRYLL VMKGAPERIL DRCSTILLNG AEEPLKEDMK 
541:	EAFQNAYLEL GGLGERVLGF CHFALPEDKY NEGYPFDADE PNFPTTDLCF VGLMAMIDPP 
601:	RAAVPDAVGK CRSAGIKVIM VTGDHPITAK AIAKGVGIIS EGNETIEDIA ARLNIPIGQV 
661:	NPRDAKACVV HGSDLKDLST EVLDDILHYH TEIVFARTSP QQKLIIVEGC QRQGAIVAVT 
721:	GDGVNDSPAL KKADIGVAMG ISGSDVSKQA ADMILLDDNF ASIVTGVEEG RLIFDNLKKS 
781:	IAYTLTSNIP EITPFLVFII GNVPLPLGTV TILCIDLGTD MVPAISLAYE QAESDIMKRQ 
841:	PRNPKTDKLV NERLISMAYG QIGMIQALGG FFSYFVILAE NGFLPMDLIG KRVRWDDRWI 
901:	SDVEDSFGQQ WTYEQRKIVE FTCHTSFFIS IVVVQWADLI ICKTRRNSIF QQGMKNKILI 
961:	FGLFEETALA AFLSYCPGTD VALRMYPLKP SWWFCAFPYS LIIFLYDEMR RFIIRRSPGG 
1021:	WVEQETYY