2.A.6.2.34
Multidrug efflux pump, MexPQ-OpmE; export fluoroquinolones, tetracycline, macrolides and chloramphenicol (Poole, 2008)
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| Accession Number: | Q4LDT6 |
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| Protein Name: | MexQ |
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| Length: | 1053 |
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| Molecular Weight: | 112308.00 |
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| Species: | Pseudomonas aeruginosa GN=mexQ PE=4 SV=1 [287] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Virion membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
macrolide, fluoroquinolone antibiotic, chloramphenicol, tetracycline |
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| Pfam: |
PF00873
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[1] “Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa.” Mima T. et.al. 16301811
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1: MTFPRFFIDR PIFAIVLSVL MMIGGIVSFF QLPLSEYPAV TPPTVQVTTA YPGANPDVIA
61: QTVATPLEQA ITGVEGMLYM SSQSATDGRM ILTITFDQHI DPDMAQIQVQ NRVSRVLSRL
121: PDEVQRQGVV TQKTSPDILM VVHLLSPEQR YDPLYISNYA YLQVRDELLR LPGISDVVVW
181: GAGEYSMRLW LDPDLIAARG LTAGEVIAAV REQNVQVAAG AVGQAPDSTA AFQVTVNTLG
241: RLSDEEQFGD IIVRTGADGQ VTRLRDVARI EMGGDAYALR SLLDGEPAVA LQIIQSPGAN
301: ALDTAEAVRA TVARLEGNFP AGLSARIAYD PTVFVRASLQ TVATTLLEAI LLVVVVVVLF
361: LRSWRASLIP LMAVPVSLVG TFAVMHLMGF SLNTLSLFGL VLSIGIVVDD AIVVVENVER
421: HIENGEPPLQ AARRAMDEVT GPIMAITSVL AAVFIPTAFL SGLQGEFYRQ FALTIAISTI
481: LSALNSLTLS PALAGLLLRP RPAGGAVAGR FQRLLQVLGR PLRNAPEAYG NAVRKVVRVS
541: GLALVVYGGL LGLTWVGFQA VPPGFVPMQD KYYLIGIAQL PNGASLERTD AVVRQMSRIG
601: LDEPGVESVV AFPGLSVNGF VNVPNAAVMF FMLDPFESRT SADLGALAIA GRLQARFASI
661: PDGFLGVFPP PPVPGLGTIG GFKMQVEDRG GAGLEALARQ TQVLMMKATE SGQLGGLMTS
721: FDINAPQLEV VVDRTKVKSQ GVRLADVFEA LQVYLGSLYI NDFNRFGRTY KVTAQADAPH
781: RMQAEAIGRL QVRNAAGAML PLSSFVTVTP SSGPDRVIHY NGYPSADISG GALPGVSSGQ
841: AVALMERLAG EVLPEGMTFE WTDLTYQQKL AGNSALFIFP LCVLLAYLIL AAQYNSWLLP
901: LAVLLIVPMC LLSAIAGVWL VGGDNNVFVQ IGLVVLVGLA AKNAILIVEF ARTLEAEGAR
961: ALEAVVEACR LRLRPILMTS LAFIAGVVPL VMASGAGAEM RQAMGVAVFA GMLGVTLFGL
1021: FLTPVFYVLV RALAARLERR AGGSLAHLEG GRP