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3.A.1.15.21
Mn2+ ABC uptake system, MntABC. Titratable transmembrane residues and a hydrophobic plug are essential for manganese import via the Bacillus anthracis ABC transporter MntBC-A (Kuznetsova et al. 2021). Zinc is a high-affinity inhibitor. The transmembrane metal permeation pathway is lined with six titratable residues that can coordinate the positively charged metal, and mutagenesis studies showed that they are essential for manganese transport. Modelling suggested that access to these titratable residues is blocked by a ladder of hydrophobic residues, and ATP-driven conformational changes open and close this hydrophobic seal to permit metal binding and release. The conservation of this arrangement of titratable and hydrophobic residues among ABC transporters of transition metals suggests a common mechanism (Kuznetsova et al. 2021).

Accession Number:Q4V0W5
Protein Name:Manganese ABC transporter, permease
Length:288
Molecular Weight:31328.00
Species:Bacillus cereus (strain ZK / E33L) [288681]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate manganese(2+)

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FASTA formatted sequence
1:	MKIVEFIDAL MQYSFLQKAL LTSVMVGIIC GVIGCFIILR GMALMGDAIS HAVLPGVALS 
61:	YMIGMNYFIG AVLTGVITAV GIGFVSQNSR IKHDMAIGIM FTSVFAVGII LITFMKSSSD 
121:	LYHILFGNVL SVRSSDMWMT LIIGVVIIGL VMLFYKELLV STFDPTMAQS YGLPNKWIHY 
181:	GLMILLTMVT VASLQTVGII LVVAMLITPA ATAYLLTNRL WVMIYLAAGI GALSSVVGLY 
241:	FSFSYNLASG ATIVLVATFL FGLAFFFSPS QGLFWRAIKI RKNRAELS