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3.A.1.110.7
Exporter for heme-binding protein, HasA and metaloprotease, PrtA.  Functions as a complex spanning the two membranes of the cell envelope: HasDEF (HasD = ABC protein; HasE = the MFP; HasF = the OMF (see 2.A.6.2.31 for HasF) (Akatsuka et al. 1997).

Accession Number:Q53368
Protein Name:HasD aka Protease SM transporter
Length:576
Molecular Weight:60869.00
Species:Serratia marcescens [615]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Pfam: PF00005   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0030256 C:type I protein secretion system complex
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0008233 F:peptidase activity
GO:0008565 F:protein transporter activity
GO:0030253 P:protein secretion by the type I secretion s...
GO:0055085 P:transmembrane transport

References (2)

[1] “Identification of two components of the Serratia marcescens metalloprotease transporter: protease SM secretion in Escherichia coli is TolC dependent.”  Letoffe S.et.al.   8226679
[2] “Iron acquisition from heme and hemoglobin by a Serratia marcescens extracellular protein.”  Letoffe S.et.al.   7937909

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSVLAAYRRG FWGIALFTAV INLLMLAPAL YMLQVYDRVL PSGNRMTLAM LTLMVVGLYL 
61:	FMGLLEWVRS QVVIRLGAQM DMRLNQRVYD AAFETNLKTG NPLAGQALND LTNLRQFATG 
121:	NALFAFFDAP WFPVYLLVVF LLHPWLGALA SAGCDRAGAA GLAQSAGCRK RLSAEARPGS 
181:	RCAHTAGQPA NLRNAEAIAA MGMLTDLRLR WLRQHQQFLL LQNRASEKIA AVTAWSKTVR 
241:	LALQSLMLGC GALLAVSGDI TPGMMIAGSI LIGRVLGPID QLIGAWKQWS SARQSLQRLE 
301:	VMLAANPPRI PSLPLPAPGG ALTVSQLTAS APGGTAPVLH GVSFRLEAGE VLGVIGASGS 
361:	GKTLLMRQLV GALTPISGDG GAEQLGPHIG YLPQDIQLFA GTLTDNIARF GQVDAEKVVA 
421:	AAALAGVHQL ILHLPKGYET ELGEGGSGLS GGQRQRVALA RALYGSPALV VLDEPNANLD 
481:	REGEEALQRA IEALKARGNT IVLVTHKPAI LATTDKLLVL TAGQVQHFGP SDAILKKLPG 
541:	FAPAAAVAPA NTGRSNGGFN VNYANFAKTA SGERKV