3.A.1.122.14
ABC transporter of unknown function, but aspects of its structure and mechanism of action are known (Yuan et al. 2001; Zoghbi and Altenberg 2013). Nucleotide-binding domain dimerization occurs as a result of binding to the natural nucleotide triphosphates, ATP, GTP, CTP and UTP, as well as the analog ATP-gamma-S. All the natural nucleotide triphosphates are hydrolyzed at similar rates, whereas ATP-gamma-S is not hydrolyzed. The non-hydrolyzable ATP analog AMP-PNP, frequently assumed to produce the nucleotide-bound conformation, failed to elicit nucleotide-binding domain dimerization (Fendley et al. 2016).
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| Accession Number: | Q58207 |
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| Protein Name: | Uncharacterized ABC transporter permease MJ0797 |
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| Length: | 367 |
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| Molecular Weight: | 41039.00 |
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| Species: | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) [243232] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MYFELAKRNL KRNLLRSILA LLGIIIGVAA ISSLGILGGG LKQGIMENLG SISNYIIVFP
61: NYQNGYTSFD KRDIEKLRVL NCKVIPVYAT SDFVYIKGKN RKAYANIFGI DKNDIKYLNL
121: KVKVSDTSVA VDTFFSNVND VNVGNQLEIK NISLRICGIY NSTFLFPDNS LILTAKTYRR
181: FYGENNYNYS RIILYVKNIN DIDKIKNETD KILNRKEKKC IIISLNSILE AINGVITKVS
241: YFLMGIGAIS LLVAGIGIGN VMLMSVVERT TEIGVMRSIG ASKKDIIILF LYEALILGVI
301: GSLIGAFLSL FFGYLIVHYL LKTSLSYYAI FYMIIGIIFG ILTSLISALY PAYKASKLDP
361: IKSLRNE