3.A.15.2.1
The pilin secretion/fimbrial assembly system. The PilB and PilT ATPases act antagonistically in Type IV pilus function in Myxococcus xanthus. ATP binding and hydrolysis by PilT are essential for T4P extension while ATP binding and hydrolysis by PilB are essential for T4P retraction. Thus, PilB and PilT act at distinct steps in the T4P extension/retraction cycle (Jakovljevic et al., 2008).
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| Accession Number: | Q59652 |
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| Protein Name: | FimU aka PA4550 |
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| Length: | 168 |
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| Molecular Weight: | 18140.00 |
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| Species: | Pseudomonas aeruginosa [287] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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| RefSeq: |
NP_253240.1
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| Entrez Gene ID: |
879606
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| BioCyc: |
PAER208964:PA4550-MONOMER
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| KEGG: |
pae:PA4550
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[1] “Identification of a gene, pilV, required for type 4 fimbrial biogenesis in Pseudomonas aeruginosa, whose product possesses a pre-pilin-like leader sequence.” Alm R.A. et.al. 7565109
[2] “Identification of two genes with prepilin-like leader sequences involved in type 4 fimbrial biogenesis in Pseudomonas aeruginosa.” Alm R.A. et.al. 8682785
[3] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.” Stover C.K. et.al. 10984043
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1: MSYRSNSTGF TLIELLIIVV LLAIMASFAI PNFKQLTERN ELQSAAEELN AMLQYARSEA
61: VSQRRAISIQ ALKDKDWGKG LSIGVLASGS IAAPLRKHDG FRAATLTAKE KSAVEHLTFT
121: ANGTLVPPTE RTFAICQNGK TDGGRVLSIS QAGRIQLEPS SKAPQSCY