1.A.17.4.13
Tmc1/Tmc2a or Tmc2b/protocadherin 15a (Pcdh15a). The complex is part of a mechanotransduction system (Maeda et al. 2014). Its trafficing to the plasma membrane depends on the transmembrane O-methyltransferase (TOMT/LRTOMT; 259 aas, 1 N-terminal TMS) (Erickson et al. 2017). Water motion is dependent on this complex (Chou et al. 2017). The role of another protein, Tmie (see TC# 8.A.115), in sensory hair cells is to target and stabilize the Tmc channel subunits to the stereocilia, the site of mechano-electrical transduction (Pacentine and Nicolson 2019). Tmc proteins 1, 2a and 2b are essential for zebrafish hearing although Tmc1 is not, probably because they can (at least partially) substitute for each other (Chen et al. 2020). There are two distinct cell types in inner ear hairs, an upper layer of teardrop shaped cells that rely on Tmc2a, and a lower layer of gourd shaped cells that rely on Tmc1/2b (Smith et al. 2020). Tmc reliance in the ear is dependent on the organ, subtype of hair cell, position within the ear, and axis of best sensitivity (Zhu et al. 2020).
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| Accession Number: | Q5ICW6 |
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| Protein Name: | Protocadherin 15a |
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| Length: | 1796 |
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| Molecular Weight: | 197333.00 |
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| Species: | Danio rerio (Zebrafish) [7955] |
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| Number of TMSs: | 1 |
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| Substrate |
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1: MRRRWWRLDC LGSAIALFVI ISQISAQNTE DWHYEECKLS RSGPPATIVT IDEESPNGTI
61: LVENMQINGR ARDPDRTISL TLLDNYDYWV ILDPALQRLF LNSTGRVLDR DPPSSITTIV
121: VQIQCTNELV GTVILHEVRI VVRDRNDNTP RFQQPRYYVS VNELTPVGTT IFTGFSGNNG
181: ATDIDDGPNG QIEYAIQYNP NDPMSNRTVR IAGTLSGNIV LAERLNYEER TRYLIIVQAN
241: DRAPYPGTRR TATTTLTLDV LDGDDLGPMF LPCVLVNNTQ DCNPVTYRVA IPELTDPNKL
301: NPLNVTPPIR AIDQDRNIQP PSDRPGILYF ILVGTPSTYP EFFTLNRSTA ELRLLKSVDR
361: ELYQRFSLVI KAEQDNGHPL PAYSKLEIEI LDENNQAPYF QQSSYRGFVS ESSSVGTTIS
421: ASANLTAPLA IIALDNDIEE TKDPQLKITL NEYTSIFTIT TSGITRFLTL LKPVDREIQT
481: NYTLTLVATD GVQQSRPVTV DILVIDANDN TPTFAQVSYS VEIFTNMLPG ETVLQLMAQD
541: ADAGLNGLIT YAILAGDHGD FIINNRTGRI TLAPGVMLTV GRSYALTVRA ADNAPDTERR
601: SSITTVYIEV LPPNNQSPPR FPLQTYNLEI SEAMRIGAIL LNLQATDREL DPITYRIETG
661: DPQEVFNLSR TIGLLLLAKP LDRETIDQYR LIVTASDGHP GGISTATVSI VITDVNDNDP
721: TFDLTLPRNL TVREEEANVF VGQVRATDPD GGLNGQVRYR LLSFASLFSI NSTGSIFTAV
781: PLDRETRSRY DLIVEASDGA VDPRRTTITL LVEVLDINDN SPVFSQPVYT VNVPENTPAG
841: SIILRLTAVD ADLVSNVTYR IKTEAALQLF AVNRLTGVIS VLQALDFESL AAGNSTYTFE
901: VEALDHGGVL PPGTATVSVR ITDMNDFSPV FRQALYKGLV APNAEKGTVI TTVLAEDQDP
961: PGTPASKVRY RVDQELSPYS GSIFDVETDT GLVITKVNLN EQPTTVFKLV VMAYDDGEPV
1021: KTNRTTVEIT VLQPSRIPIF TEEEYRFSPV SENAPIGTPV GLILAAATNT TVVYSIVSGN
1081: EGGVFTVNKS TGIIYTNKSL DYENVTSYVL RVQADSLTVI LANLRAPSKT NTAKVFINVQ
1141: DENDHPPVFS RQVYIGGVTE DTKTFTTVLK IVATDVDTGN YSKMAYRLII PPTTEGQDSF
1201: VIEPYTGVIK SAIMFRNMRR SYFKFQVVAT DDYGKGLTSK ADVVVSVVNA LDMQVVVSNV
1261: PPTVVEENKE QLISILERYV QDQIPGAKVI VESIGPRRHG EGYELEDYSK SDLQVYAIDP
1321: LTNRAISRQE LFKFLDGKIL DINKEFQPYL GEGGRILEIR SPDIVATVKK AAQAVGYTEG
1381: ALLALAIIII LCCIPAILIV MVTYKQFKER QAECAKTARI QMALPAGKST GGGGGGGGGG
1441: GGGGGAQTNL YEELGDGGML GLQRRRRSVI EEADRQSLIR NFASRAIAAH KQTTGNGQMR
1501: SKLPKSESAI TFLSDERPLT TQNPIFQDGL SSSPEPNLEV RRISGFLYSD PPSPTSPCGQ
1561: FTSWSLPSRI RGRGFYSTLR RQALWDPAQW EEQQLKAELT DSREELDADQ SGRSTETKLS
1621: VREQARQFEA LADRTPRQSR DSYASLDPDD PLLGTIMLSY STISVGKDSP PCIIITGDDG
1681: ETPPPPTAQR PTPPVVRKFS SSISNYMTVE PCEILLEFIS DFPGSPPPSP PSLVPSRSFL
1741: SPPCLELDCT PPPTPPPIQS PEIPVQCPTF KPKGILKNSD RFGCSPDVKY DNKNDV