3.A.15.2.1
The pilin secretion/fimbrial assembly system. The PilB and PilT ATPases act antagonistically in Type IV pilus function in Myxococcus xanthus. ATP binding and hydrolysis by PilT are essential for T4P extension while ATP binding and hydrolysis by PilB are essential for T4P retraction. Thus, PilB and PilT act at distinct steps in the T4P extension/retraction cycle (Jakovljevic et al., 2008).
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| Accession Number: | Q60148 |
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| Protein Name: | PilE aka PA4556 |
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| Length: | 141 |
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| Molecular Weight: | 15279.00 |
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| Species: | Pseudomonas aeruginosa [287] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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| RefSeq: |
NP_253246.1
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| Entrez Gene ID: |
878451
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| Pfam: |
PF07963
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| BioCyc: |
PAER208964:PA4556-MONOMER
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| KEGG: |
pae:PA4556
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[1] “The pilE gene product of Pseudomonas aeruginosa, required for pilus biogenesis, shares amino acid sequence identity with the N-termini of type 4 prepilin proteins.” Russell M.A. et.al. 7854130
[2] “Identification of a gene, pilV, required for type 4 fimbrial biogenesis in Pseudomonas aeruginosa, whose product possesses a pre-pilin-like leader sequence.” Alm R.A. et.al. 7565109
[3] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.” Stover C.K. et.al. 10984043
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1: MRTRQKGFTL LEMVVVVAVI GILLGIAIPS YQNYVIRSNR TEGQALLSDA AARQERYYSQ
61: NPGVGYTKDV AKLGMSSANS PNNLYNLTIA TPTSTTYTLT ATPINSQTRD KTCGKLTLNQ
121: LGERGAAGKT GNNSTVNDCW R