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1.G.10.1.1 The herpes envelope glycoprotein class III membrane fusion system including glycoproteins gB, gD, gH and gL. There are two fusion peptides of 8 aas each that form a bipartite system (Apellániz et al. 2014; Feng and Jia 2016).
Accession Number:	Q69091
Protein Name:	Envelope glycoprotein D
Length:	394
Molecular Weight:	43347.00
Species:	Human herpesvirus 1 (strain 17) (HHV-1) [10299]
Number of TMSs:	3
Location¹ / Topology² / Orientation³:	Virion membrane¹ / Single-pass type I membrane protein²
Substrate	molecule

Structure:
Pfam:	PF01537
Gene Ontology GO:0016021 C:integral to membrane GO:0055036 C:virion membrane GO:0046872 F:metal ion binding GO:0044419 P:interspecies interaction between organisms
References (6) [1] “Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1.” McGeoch D.J.et.al. 2984429 [2] “The DNA sequences of the long repeat region and adjoining parts of the long unique region in the genome of herpes simplex virus type 1.” Perry L.J.et.al. 2846760 [3] “Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus.” Ushijima Y.et.al. 17218138 [4] “Disulfide bond structure of glycoprotein D of herpes simplex virus types 1 and 2.” Long D.et.al. 1328685 [5] “Complexes between herpes simplex virus glycoproteins gD, gB, and gH detected in cells by complementation of split enhanced green fluorescent protein.” Avitabile E.et.al. 17670828 [6] “Virion incorporation of the herpes simplex virus type 1 tegument protein VP22 occurs via glycoprotein E-specific recruitment to the late secretory pathway.” Stylianou J.et.al. 19279114
3U82

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MGGAAARLGA VILFVVIVGL HGVRSKYALV DASLKMADPN RFRGKDLPVL DQLTDPPGVR 
61:	RVYHIQAGLP DPFQPPSLPI TVYYAVLERA CRSVLLNAPS EAPQIVRGAS EDVRKQPYNL 
121:	TIAWFRMGGN CAIPITVMEY TECSYNKSLG ACPIRTQPRW NYYDSFSAVS EDNLGFLMHA 
181:	PAFETAGTYL RLVKINDWTE ITQFILEHRA KGSCKYALPL RIPPSACLSP QAYQQGVTVD 
241:	SIGMLPRFIP ENQRTVAVYS LKIAGWHGPK APYTSTLLPP ELSETPNATQ PELAPEDPED 
301:	SALLEDPVGT VAPQIPPNWH IPSIQDAATP YHPPATPNNM GLIAGAVGGS LLAALVICGI 
361:	VYWMRRHTQK APKRIRLPHI REDDQPSSHQ PLFY

1.G.10.1.1
The herpes envelope glycoprotein class III membrane fusion system including glycoproteins gB, gD, gH and gL. There are two fusion peptides of 8 aas each that form a bipartite system (Apellániz et al. 2014; Feng and Jia 2016).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

1.G.10.1.1The herpes envelope glycoprotein class III membrane fusion system including glycoproteins gB, gD, gH and gL. There are two fusion peptides of 8 aas each that form a bipartite system (Apellániz et al. 2014; Feng and Jia 2016).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

1.G.10.1.1
The herpes envelope glycoprotein class III membrane fusion system including glycoproteins gB, gD, gH and gL. There are two fusion peptides of 8 aas each that form a bipartite system (Apellániz et al. 2014; Feng and Jia 2016).