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2.A.6.2.31
Multidrug efflux pump, SdeAB-HasF (mediates fluoroquinolone efflux) (Begic and Worobec, 2008) (HasF is > 60% identical to TolC of E. coli (1.B.17.1.1))

Accession Number:Q6GW09
Protein Name:HasF
Length:505
Molecular Weight:54430.00
Species:Serratia marcescens [615]
Location1 / Topology2 / Orientation3: Nucleus1
Substrate fluoroquinolone antibiotic

Cross database links:

Pfam: PF02321   

Gene Ontology

GO:0019867 C:outer membrane
GO:0005215 F:transporter activity
GO:0015031 P:protein transport

References (1)

[1] “HasF, a TolC-homolog of Serratia marcescens, is involved in energy-dependent efflux.”  Kumar A.et.al.   16121228

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MKKLLPLLIG LSLGGFSAMS QAENLLQVYK QARESNPDLR KSAADRDAAF EKINEARSPL 
61:	LPQLGLTAGY DYTNGYRDSN GVNSNVTSGS LALTQTLFDM SKWRQLTLQE KTAGISDVTF 
121:	QTAEQQLILN TATAYFNVLK AIDTLSYTQA QKDAVYRTLD QTTQRFTWGL VAITDVQNAR 
181:	SNYDTVLAAE VSARNDLDNA LETLRQVTGA FYPELASLNT DRFSTQRPEA VNNLLKEAEA 
241:	RNLSLLSARL SQDLAREQIR AAQTGYMPTI DVSASTGISN TKYNGSNTGG ANAARYSDSD 
301:	AGQNKVGISF NLPLYSGGAT NSQVKQAQYG FVGASEQLES SHRSVVQTVR SSFNNVNVSI 
361:	SSINAYKQAV ISAQSSLDAM EAGYQVGTRT IVDVLDATTT LYNAKRQLSD ARYTYLINQL 
421:	NIKSALGTLN QNDLLLLNGA LGKPVSTAPD AVAPQNRAQD AYADGYQDNA PMQQTAAPAP 
481:	AATRASAPAV TTSQPARNSG NPFRN