1.G.22.1.1
The gO or gL glycoprotein fusogen of 278 aas and 3 TMSs, 1 N-terminal and 2 near the C-terminus (Feng and Jia 2016). The heterodimer glycoprotein H (742 aas; 2 TMSs, N- and C-terminal)-glycoprotein
L is required for the fusion of viral and plasma membranes leading to
virus entry into the host cell. Membrane fusion is mediated by the
fusion machinery composed at least of gB (907 aas; 3 TMSs, 1 N-terminal and 2 near the C-terminus; similar to gB of 1.G.10.1.1) and the heterodimer gH/gL.
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| Accession Number: | Q6SW67 |
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| Protein Name: | Envelope glycoprotein H |
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| Length: | 742 |
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| Molecular Weight: | 84321.00 |
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| Species: | Human cytomegalovirus (strain Merlin) (HHV-5) [295027] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Virion membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
molecule |
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1: MRPGLPSYLI ILAVCLFSHL LSSRYGAEAV SEPLDKAFHL LLNTYGRPIR FLRENTTQCT
61: YNSSLRNSTV VRENAISFNF FQSYNQYYVF HMPRCLFAGP LAEQFLNQVD LTETLERYQQ
121: RLNTYALVSK DLASYRSFSQ QLKAQDSLGE QPTTVPPPID LSIPHVWMPP QTTPHGWTES
181: HTTSGLHRPH FNQTCILFDG HDLLFSTVTP CLHQGFYLID ELRYVKITLT EDFFVVTVSI
241: DDDTPMLLIF GHLPRVLFKA PYQRDNFILR QTEKHELLVL VKKDQLNRHS YLKDPDFLDA
301: ALDFNYLDLS ALLRNSFHRY AVDVLKSGRC QMLDRRTVEM AFAYALALFA AARQEEAGAQ
361: VSVPRALDRQ AALLQIQEFM ITCLSQTPPR TTLLLYPTAV DLAKRALWTP NQITDITSLV
421: RLVYILSKQN QQHLIPQWAL RQIADFALKL HKTHLASFLS AFARQELYLM GSLVHSMLVH
481: TTERREIFIV ETGLCSLAEL SHFTQLLAHP HHEYLSDLYT PCSSSGRRDH SLERLTRLFP
541: DATVPATVPA ALSILSTMQP STLETFPDLF CLPLGESFSA LTVSEHVSYI VTNQYLIKGI
601: SYPVSTTVVG QSLIITQTDS QTKCELTRNM HTTHSITVAL NISLENCAFC QSALLEYDDT
661: QGVINIMYMH DSDDVLFALD PYNEVVVSSP RTHYLMLLKN GTVLEVTDVV VDATDSRLLM
721: MSVYALSAII GIYLLYRMLK TC