2.A.6.2.18
The polycyclic aromatic hydrocarbon (phenanthrene; anthacene; fluoranthene)/drug (chloramphenicol; nalidixic acid) exporter, EmhABC (Hearn et al., 2003; 2006)
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| Accession Number: | Q6V6X8 |
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| Protein Name: | Inner membrane pump protein emhB |
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| Length: | 1048 |
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| Molecular Weight: | 112591.00 |
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| Species: | Pseudomonas fluorescens [294] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
chloramphenicol, nalidixic acid, phenanthrene, fluoranthene |
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| Pfam: |
PF00873
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[1] “Identification and characterization of the emhABC efflux system for polycyclic aromatic hydrocarbons in Pseudomonas fluorescens cLP6a.” Hearn E.M. et.al. 14563857
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1: MSRFFIDRPI FAWVIALVIM LVGALSILKL PINQYPSIAP PAIAIQVTYP GASAQTVQDT
61: VVQVIEQQLN GIDNLRYVSS ESNSDGSMTI TATFEQGTNS DTAQVQVQNK LNLATPLLPQ
121: EVQQQGIRVT KSVKNFLLVI GVVSRDGSMT KDDLSNYIVS NMQDPISRTA GVGDFQVFGS
181: QYAMRVWLDP AKLNNFSLTP VDVKAAIAAQ NIQVSSGQLG GLPAAPGQQL NATIIGKTRL
241: QTAEQFNKIL LKVNKDGSQV RLSDVADVGL GGENYSINAQ FNGAPASGLA VKLANGANAL
301: DTAKALRNTI NTLKPFFPQG MEVVFPYDTT PVVTESIKGV VETLVEAIVL VFLVMFLFLQ
361: NFRATVITTM TVPVVLLGTF GILAAFGFSI NTLTMFGMVL AIGLLVDDAI VVVENVERVM
421: SEEGLSPKEA TKKSMGQIQG ALVGIALVLS AVLLPMAFFS GSTGVIYKQF SITIVSAMAL
481: SVLVALIFTP ALCATMLKAI PKGEHGTPKR GFFGWFNRSF DRGVKSYERG VGNMLAHKAP
541: YLLAYLIIVV GMIWLFTRIP TAFLPEEDQG VLFAQVQTPA GSSAQRTQVV IDEMRSYLLD
601: KESSAVASVF TVNGFNFAGR GQSSGLAFIM LKPWDQRDAE NSVFKLAARA QQHFFTFRDA
661: MVFAFAPPAV LELGNATGFD VFLQDRAGIG HEKLMEARNQ FLGMAAQSKV LYQVRPNGLN
721: DEPQYQLEID DEKASALGIT LSDINSTLSI ALGSSYVNDF IDRGRVKKVY VQGQPGSRMS
781: PEDIKKWYVR NSAGTMVPFS AFAKGQWIYG APKLSRYNGV EAMEILGAPA PGYSTGEAMA
841: EVEALAKKLP AGVGISWTGL SYEERLSGSQ APALYALSLL MVFLCLAALY ESWSIPIAVM
901: LVVPLGIIGA LLATSLRGLS NDVYFQVGLL TTIGLAAKNA ILIVEFAKEL HEQGRSLRDA
961: AIEACRMRLR PIIMTSLAFV LGVVPLAIST GAGSGSQHAI GTGVIGGMIT ATVLAIFWVP
1021: LFFVTVSSIG QRKTADQDDA IEPSKEAG