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2.A.6.2.23
The multidrug (β-lactams, aminoglycerides (gentamycin and streptomycin) macrolides (erythromycin) and dye (acriflavin)) efflux pump, BpeAB-OprB (Chan et al., 2004; Chan and Chua, 2005). It also exports acyl homoserine lactones including N-octanoyl-homoserine lactone, N-decanoyl-homoserine lactone, N-(3-hydroxy)-octanoyl-homoserine lactone, N-(3-hydroxy)-decanoyl-homoserine lactone, N-(3-oxo)-decanoyl-homoserine lactone, and N-(3-oxo)-tetradecanoyl-homoserine lactone (Chan et al., 2007). Q9HWH6 is a DoxX family member (see 9.B.214.2).

Accession Number:Q6VV67
Protein Name:OprB
Length:532
Molecular Weight:57254.00
Species:Burkholderia pseudomallei (Pseudomonas pseudomallei) [28450]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate beta-lactam, streptomycin, gentamycin, erythromycin A, 3,6-diamino-10-methylacridinium chloride, N-acyl homoserine lactone

Cross database links:

Pfam: PF04248    PF02321   

Gene Ontology

GO:0016020 C:membrane
GO:0008289 F:lipid binding
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “BpeAB-OprB, a multidrug efflux pump in Burkholderia pseudomallei.”  Chan Y.Y.et.al.   15047512

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MKRKHALTAL AVALLAAGCT LAPRYERPAA PVSGAFPADG VYAAQPGAAP GARSANGQAA 
61:	VDIGWREFFV DPRLQRLIEI ALKNNRDLRV SVLNVEASRA QYQITRAGLF PTLSGTGTGT 
121:	IQRTPAGVSI TGQPLISRTY NVGVSASWEL DLFGRVQSLK DQALAQYFAT AQARKAAEIS 
181:	LVASVADQYL TLLSTDDLLQ VTQNTLKSAR ASYDLTKLQF DNGTGSELDL RQAQTVVETA 
241:	LASQQAQARA RAQALNALVL LIGEPLPDDL PAGLPLNAQN LLTDIPAGLP SDLLTRRPDI 
301:	MQAEETLRAA NANIGAARAA FFPKISLTSA FGTASPTLGG LFKAGTAAWS FAPNIALPIF 
361:	EGGQNIANLD LAHVQKRIEI ANYEKAIQSA FREVSDGLAA RGTYDQQIAA LERNEHAQQR 
421:	RYDLSDLRYR NGVDSYLSVL TAQTDLYSAQ HQLISARLAR WTNLVDLYRA LGGGWLEHCA 
481:	HKGPATYFHL HTEDGVIENA AWSYEEPSGI ANAIRQYVAF DAACVDRIDV TS