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3.D.1.5.1
Proton-translocating NADH dehydrogenase I.  NDUFS4 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  However, a knockout of NDUFS4 in human iPSCs provides a model for mitochondrial complex I deficiencyin humans (Goolab et al. 2025).

Accession Number:Q746T7
Protein Name:NuoL aka GSU3431
Length:624
Molecular Weight:66596.00
Species:Geobacter sulfurreducens [35554]
Number of TMSs:17
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

RefSeq: NP_954471.1   
Entrez Gene ID: 2686884   
Pfam: PF00361    PF00662   
BioCyc: GSUL243231:GSU_3431-MONOMER   
KEGG: gsu:GSU3431   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008137 F:NADH dehydrogenase (ubiquinone) activity
GO:0042773 P:ATP synthesis coupled electron transport

References (1)

[1] “Genome of Geobacter sulfurreducens: metal reduction in subsurface environments.”  Methe B.A.et.al.   14671304

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MKLYLALILL LPLLGGTLNA LVGRKLPRRL CEALACAAVW GAFVCAALAF AAYEAPETVL 
61:	LATWLADFDF TAPIALYLDP LSLVMTVMIT FVCGLIHLYA VGYMAGEGSP ARFFALLNLF 
121:	VFAMLVLILA ENLPLLYLGW EGVGFCSYAL IGFWYSDPKN ATAGRKAFIT TRIGDTAFGI 
181:	GIVWCFQLFQ TESISQINQM GFLMPVGVVT ALGLLFLAGA MGKSAQVPLM VWLPDAMAGP 
241:	TPVSALIHAA TMVTAGVYLM ARMSPLFSAA PVVMAAVAIT GAVTAFYGAT CALVQRDFKR 
301:	VLAYSTISQI GYMMLGVGAG AVTAATFHLL VHAFFKALLF LGAGCVIAAL HHEQDLFRMG 
361:	GLRRKMPVTF WAFMAGAACL AGLPPTGGFF SKDAILAAVW AKGGALYGGL FGLGLMAALL 
421:	TSFYTFRMVY LVFGGEGATE VHRNPRIMDL MLLPLAILGL IGGFIHLPAF LADGWLGRFL 
481:	ATTLTEGAAH LSHGEEMAVE AIAALVALTG LAIAHYRYGG IRRAARIEAA AAEPRGITAF 
541:	LLNGWYADHL YRALFIRPYE AIASFLWRRV DEGVIDVSLD RLADGIGTAG QGLGRWSCGR 
601:	VSVYLLSFAA GLALVLGWLA WGRI