Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.D.1.5.1
Proton-translocating NADH dehydrogenase I.  NDUFS4 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  However, a knockout of NDUFS4 in human iPSCs provides a model for mitochondrial complex I deficiencyin humans (Goolab et al. 2025).

Accession Number:Q746T9
Protein Name:NuoN aka GSU3429
Length:466
Molecular Weight:47875.00
Species:Geobacter sulfurreducens [35554]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

RefSeq: NP_954469.1   
Entrez Gene ID: 2686885   
Pfam: PF00361   
BioCyc: GSUL243231:GSU_3429-MONOMER   
KEGG: gsu:GSU3429   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008137 F:NADH dehydrogenase (ubiquinone) activity
GO:0042773 P:ATP synthesis coupled electron transport
GO:0006810 P:transport

References (1)

[1] “Genome of Geobacter sulfurreducens: metal reduction in subsurface environments.”  Methe B.A.et.al.   14671304

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MTIADLWTIM PLLLLACGSV LVLILGAIVP GRYGTAIGVA VCAGAALWAL QTPPRPLAPT 
61:	LGVAFTPFAR SFLVLFAVTA LLSLLLAHDH ADRQGLEGEE YPATILFGAF GMGVVASAAN 
121:	FLTLFLGLEA LTFAFYILVA YDRNRPASGE AGLKYLLMGA VSAAFVAFGI ALLYGATGSL 
181:	EIGRAVAASA AGGGIALAGW GLLLAGLAFK VSLAPAHLWT PDVYQGGPTP VTAFLAAGSK 
241:	GAAIALFLLI LPPLGEIGPL RAPLWGLALL SMAVGNLAAL LQPNVKRMLA YSSVAQMGYV 
301:	ALALLSGGRG YEAAAFYAVA YGVMSLAAFG ALASLEQERP LEQVDELRGI GYRRPFQGVV 
361:	LAVAMFALAG IPPTVGFAGK FAIFFAALRA GETPLAIIGI LTAAASAYYY LRVVVNLYMK 
421:	PAEEAAPGPL PTPAEAVCLG AVTVAILALG VWPGPLFDLV EAILKA