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1.R.1.1.1
Membrane Contact Site (MCS).  Functions include lipid and ion transport between organelles as well as organelle positioning and division (Wu et al. 2018).
Constituents include:
Seipin, 398 aas and 2 - 4 TMSs, Q96G97.
Protrudin, 411 aas and 4 - 5 TMSs, Q5T4F4.
Spastin (SPAST, ADPSP, FSP2, SPG4), 616 aas, 1 N-terminal TMS, Q9UBP0.
Vesicle-associated membrane protein-associated protein A, (VAPA, VAP33), 249 aas, 1 C-terninal TMS, a member of TC family 9.B.17), Q9P0L0.
Vesicle-associated membane protein associated, VAPB/C (see TC 9.B.17.1.1), 243 aas and 1 C-terminal TMS, O95292.
Dynamin 2 (Dyn2, Dnm2) GTPase, 870 aas, 1 TMS, see TC# 8.A.34.1.4, P50570.
Mitofusin 2 (Mfn2, CPRP1) GTPase, 757 aas, 0 - 2 TMSs, (see TC# 1.N.6.1.2), O95140.
Acyl-CoA binding domain-containing protein 5, ACBD5, 534 aas, 1 C-terminal TMS, Q5T8D3.
Mitofusin; Its heptad repeat domain 1 has membrane destabilization function in mitochondrial fusion (Daste et al. 2018).
PDZ domain-containing protein 8,
PDZD8, of 1154 aas, a molecular tethering protein that connects ER and mitochondria membranes and is a shared component of at least two distinct MCSs (Hirabayashi et al. 2017; Elbaz-Alon et al. 2020).

Accession Number:Q7L4E1
Protein Name:Mitoguardin 2
Length:593
Molecular Weight:65531.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion outer membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAFRRAEGTS MIQALAMTVA EIPVFLYTTF GQSAFSQLRL TPGLRKVLFA TALGTVALAL 
61:	AAHQLKRRRR RKKQVGPEMG GEQLGTVPLP ILLARKVPSV KKGYSSRRVQ SPSSKSNDTL 
121:	SGISSIEPSK HSGSSHSVAS MMAVNSSSPT AACSGLWDAR GMEESLTTSD GNAESLYMQG 
181:	MELFEEALQK WEQALSVGQR GDSGSTPMPR DGLRNPETAS EPLSEPESQR KEFAEKLESL 
241:	LHRAYHLQEE FGSTFPADSM LLDLERTLML PLTEGSLRLR ADDEDSLTSE DSFFSATELF 
301:	ESLQTGDYPI PLSRPAAAYE EALQLVKEGR VPCRTLRTEL LGCYSDQDFL AKLHCVRQAF 
361:	EGLLEDKSNQ LFFGKVGRQM VTGLMTKAEK SPKGFLESYE EMLSYALRPE TWATTRLELE 
421:	GRGVVCMSFF DIVLDFILMD AFEDLENPPA SVLAVLRNRW LSDSFKETAL ATACWSVLKA 
481:	KRRLLMVPDG FISHFYSVSE HVSPVLAFGF LGPKPQLAEV CAFFKHQIVQ YLRDMFDLDN 
541:	VRYTSLPALA DDILQLSRRR SEILLGYLGV PAASSAGVNG ALPRENGPLG ELQ