1.C.107.1.4
The trimeric Tc toxin complex consisting of three subunits, TcdA, TcdB
and TccC (TcA, B and C, respectively) of 2525, 1476 and 1043 aas, respectively.
Several 3-d structures and their modes of action and secretion have been
described (see the family description) (Gatsogiannis et al. 2013; Yang and Waterfield 2013; Moriya et al. 2017). Clostridioides difficile toxins TcdA and TcdB are inhibited by the amiodarone derivative dronedarone (Matylitsky et al. 2024).
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| Accession Number: | Q7MZV7 |
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| Protein Name: | Insecticidal toxin complex protein TccC1 |
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| Length: | 1043 |
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| Molecular Weight: | 111878.00 |
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| Species: | Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) [243265] |
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| Number of TMSs: | 9 |
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| Substrate |
toxin |
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1: MSTPDTALYT QTPTVSVLDN RGLSIRDIGF HRVVIGGDID TRVTRHQYDA RGYLNHSIDP
61: RLYDAKQADN SVKPNFVWQY DLAGHALRTE SVDAGRTVAL NDIEGRPVMT MNATGVRQTR
121: RYEGNTLPGR LLSVSEQVFD QETSQVTERF IWAENTTAEK EYNLSGLCIR HYDTAGVTRL
181: MSQSLAGAIL SQSHQWLAEG QEANWSGDDE TVWQRMLASE VYTTQSTTNA IGALLTQTDA
241: KGNIQRLAYD IAGQLKGSWL TVKGQREQVI VKSLSWSAAG HKLREEHGNG VITEYSYEPE
301: TQRLMGITTR RAEESQSEAR VLQDLRYEYD PVGNVISIHN DAEATRFWRN QKVEPENRYV
361: YDSLYQLMSA TGREMANIGQ QSNQLPSPAM PVPADNSTYT NYQRTYSYDR GGNLVQIRHS
421: SPATQNSYTT EMTVSSRSNR TVLSTLTTDP TQVDGLFDAG GHQKTLIPGQ NLDWNMRGEL
481: QRVTPVSREN SSDSEWYRYS SDGVRLLKVS EQQTGNSTQV QRVTYLPGLE LRITGVADKT
541: TQNLQVITVG EAGRAQVRVL HWESGKPADI DNNQVRYSYD NLLGSSQIEL DSEGQILSQE
601: EYYPYGGTAV WAAKNQTEAS YKFIRYSGKE RDATGLYYYG YRYYQPWVGR WLSADPAGTV
661: DGLNVYRMVR NNPITLTDHD GLAPSPNRNR NTFWFASFLF RKPDEGMSAS MRRGQKIGRA
721: IAGGLAIGGL AAAIAGTAGA ALPVILGVAA VGAGIGALMG YNVGSLLEKG GALLARLVQG
781: KSTLVQSAAG AAAGASSAAA YGARAQGVGV ASAAGAVTGA VGSWINNADR GIGGAIGAGS
841: AVGTIDTMLG TSSTLTHEVA AAAGGAAGGM ITGTQGSTRA GIHAGIGTYY GSWIGFGLDV
901: ASNPAGHLAN YAVGYAAGLG AEMAINRVIG GGFLGRLLGR AVSPYAAGLA RQLVHFSIAR
961: PVFEPIFSVL GGLAGGIGTG LHRVMGRDSW VSRGLSAAGS GIDHLAGMIG NQIRGRVLTT
1021: TGIANAIDYG TSAIGAARRV ISL