1.C.107.1.4
The trimeric Tc toxin complex consisting of three subunits, TcdA, TcdB
and TccC (TcA, B and C, respectively) of 2525, 1476 and 1043 aas, respectively.
Several 3-d structures and their modes of action and secretion have been
described (see the family description) (Gatsogiannis et al. 2013; Yang and Waterfield 2013; Moriya et al. 2017). Clostridioides difficile toxins TcdA and TcdB are inhibited by the amiodarone derivative dronedarone (Matylitsky et al. 2024).
|
| Accession Number: | Q7N7Y9 |
|---|
| Protein Name: | Insecticidal toxin complex protein TcdA1 |
|---|
| Length: | 2525 |
|---|
| Molecular Weight: | 285098.00 |
|---|
| Species: | Photorhabdus luminescens subsp. laumondii (strain TT01) [243265] |
|---|
| Substrate |
toxin |
|---|
1: MNSPVKEIPD VLKNQCGFNC LTDISHSSFN EFHQQVSAHL SWSEAHDLYH DAQQAQKDNR
61: LYEARILKRA NPQLQNAVHL AIIAPNVELI GYNSQFSGRA SQYVAPGTVS SMFSPAAYLT
121: ELYREARNLH ASNSVYYLDT RRPDLKSMAL SQQNMDTELS TLSLSNELLL ESIKTESKLD
181: NYTKVMEMLS TFRPSGATPY HDAYENVREV IQLQDPGLEQ LNASPAIAGL MHQASLLGIN
241: ASISPELFNI LTEEITEGNA EELYEKNFGN IEPASLAMPE YLKRYYNLSD EELSQFIGKA
301: SNFGQQEYSH NQLITPVVNS SDGTVKVYRI TREYTTNAYQ VDVELFPFGG ENYRLDYKFK
361: DFWNATYLSI KLNDKRELIR TEGAPQVNIE YSANITLSTT DISQPFEIGL TRVLPNTNYA
421: YAAAKFTVEE YNQYSFLLKL NKAIRLSRAT ELSPTILEGI VRSVNQQLDI NTEVLGKVFL
481: TKYYMQRYAI DAETALILCH ALISQRSYNN QTSQFDRLFN TPLLNGQYFS TGDEEIDLNP
541: GSNGDFRKTI LKRAFNIDDV SLYRLLKITD HNNKDGKIKN NLKDLSNLYI GKLLAEIHQL
601: TIDELDLLLV AVGEGETNLS AISDKQLTTL IRKLNTITGW LHIQKWSVFQ LFIMTSTSYN
661: KTLTPEIKNL LDTVYHGLQG FDKDKADLLH VMAPYIAATL QLSSENVAHS VLLWADKLKP
721: GDGAMTAEKF WDWLNTQYTP GLSEAVEMRE HIVQYCQALA QLEMVYHSTG INENAFRLFV
781: TKPEMFGTSI GAAPTHDALS LIMLTRFADW VNALGEKASS VLAALEANTL TAEQLADAMN
841: LDANLLLQAS TQAQNHQHLP PVTQENAFSC WTSINTILQW VNVAQQLNVA PQGVSALVGL
901: DYIQSKQKTP TYTQWENAAG ILTAGLNSQQ ADTLHAFLDE SRSAALSTYY IRQVAKPAAA
961: IKSRDDLYQY LLIDNQVSAA IKTTRIAEAI ASIQLYVNRA LENVEENADS GVISRQFFID
1021: WDKYNKRYST WAGVSQLVYY PENYIDPTIR IGQTKMMDAL LQSVSQSQLN TDTVEDAFMS
1081: YLTSFEQVAN LKVISAYHDN INNDQGLTYF IGLNETDAGE YYWRSVDHSK FSDGKFAANA
1141: WSEWHKIDCP INPYRSTIRP VMYKSRLYLL WLEQKEITKQ TGNSKDGYQT ETDYRYELKL
1201: AHIRYDGTWN TPITFDVNEK ISELKLVKNK APGLYCAGYQ GEDTLLVMFY NQQDTLDSYK
1261: TAAMQGLYIF ADMASKDMTL GQSNVYRDNS YKQFDTNSVR RVNNRYAENY EIPSSVNSNN
1321: SYGRGEYNLS MVHGGDIPII RYQASSSDLK IHISPKLRIT YEGADERTRN QCNLIKKYGK
1381: LGDKFIIYTN LSVNTQWTSN KKLIYPVYQY RGNTTNNSQG RLLFYRDNQI GKVSVFLPNW
1441: GQSLYSEVTN SNNGYIIDTS NQEPLFKQYL YMEDKNNGFR IIATDVYNAV EINTAISPAK
1501: IQVTVKAGSK EKTFTADKDV SVQPSPSFDE MYYQFNTLEI EGTGLNFNNN LASIDVTFTA
1561: LAEDGRKLGY ESFSIPVTRK VSTDNALTLH HNENGAQYMQ WQAYRTRLNT LFARQLVARA
1621: TTGIDTILSM ETQNIQEPVL WSDNFTATLP IYNSSLHGNS KNIKIMLGNS EKQPDQANVI
1681: YQGELTDKNQ LINLSETYIS IKERSNNTKP VDNKGNDSWI YLFVKYSTNP IKIGEFWFKN
1741: GTNFQGYYPK GNEKNRDPIF IENQKTEPMD FSGANSLYFW ELFYYTPMLV AQRLLHEQNF
1801: DEANRWLKYV WSPSGYIVHG QIQNYQWNVR PLLEDTSWNS DPLDSVDPDA VAQHDPMHYK
1861: VSTFMRTLDL LIARGDQAYR QLERDTLNEA KMWYMQALHL LGDKPYLPLS TTWNNPRLDR
1921: AADITTQNAH ASSIVALRQS TPAPLALRSA NTLTDLFLPQ INEVMMNYWQ TLAQRVYNLR
1981: HNLSIDGQPL YLPIYATPAD PKALLSAAVA TSQSGGKLPE SFMSLWRFPH MLENARGMVS
2041: QLIQFGSTLQ NIIERQDAEA LNALLQNQAA ELILTNLSIQ DKTIEELDVE KTVLEKSKAG
2101: AQSRFDSYSK LYDENINAGE NQAMMLRASA AGLTTAVQAS RLAGAAADLV PNIFGFAGGG
2161: SRWGAIAEAT GYVMEFSANV MNTEADKISQ SETYRRRRQE WEIQRNNAEA ELKQLDSQLK
2221: SLVVRREAAV LQKTSLKTQQ EQTQSQLAFL QRKFSNQALY NWLRGRLAAI YFQFYDLAVA
2281: RCLMAEQAYR WEINDASASF IKPGAWQGTY AGLLAGETLM LSLTQMEDAH LKRDKRALEV
2341: ERTVSLAEVY AGLPQDKGPF SLAQEIEKLV SKGSGSAGSD NNNLAFGAGT DTKTSLQASI
2401: SLADLKIRED YPTSLGKIRR IKQISVTLPA LLGPYQDVQA ILSYGDKTGL ANGCEALAVS
2461: HGMNDSGQFQ LDFNDGKFLP FEGIAIDQGT LTLSFPNASM PKKGKQATML KTLNDIILHI
2521: RYTIK