2.A.82.1.2
The organic solute transporter OSTα/OSTβ or SLC51A/SLC51B (transports the same anions as the 2.A.82.1.1 system) (The ileal enterocyte basolateral bile acid transporter; uses facilitated diffusion vian an anion:anion antiport mechanism with sulfate or bicarbonate as the counter anion) (Dawson et al., 2005). Transports steroid-derived molecules as well as glycine and taurine conjugated bile acids (Ballatori et al. 2013). Heterodimerization increases stability, facilitates post-translational modification and is required for delivery to the plasma membrane. This system is essential for intestinal bile acid and dietary lipid absorption (Ballatori et al. 2013). Four OSTalpha amino acids (Ser228, Thr229, Gln269 and Glu305) affect expression of OSTalpha/beta and may influence OSTalpha/beta-mediated bile acid transport (Murphy et al. 2021).
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| Accession Number: | Q86UW2 |
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| Protein Name: | OST beta |
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| Length: | 128 |
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| Molecular Weight: | 14346.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass membrane protein2 |
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| Substrate |
hydrogencarbonate, sulfate, taurocholic acid |
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| RefSeq: |
NP_849190.2
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| Entrez Gene ID: |
123264
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| OMIM: |
612085 gene
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| KEGG: |
hsa:123264
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[1] “Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta.” Seward D.J. et.al. 12719432
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team et.al. 15489334
[3] “OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia.” Ballatori N. et.al. 16317684
[4] “The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes.” Landrier J.-F. et.al. 16269519
[5] “FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.” Lee H. et.al. 16251721
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1: MEHSEGAPGD PAGTVVPQEL LEEMLWFFRV EDASPWNHSI LALAAVVVII SMVLLGRSIQ
61: ASRKEKMQPP EKETPEVLHL DEAKDHNSLN NLRETLLSEK PNLAQVELEL KERDVLSVFL
121: PDVPETES