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| Accession Number: | Q8CFI0 |
| Protein Name: | E3 ubiquitin-protein ligase NEDD4-like protein aka Nedd4-2 |
| Length: | 1004 |
| Molecular Weight: | 115419.00 |
| Species: | Mus musculus (Mouse) [10090] |
| Location1 / Topology2 / Orientation3: | Cytoplasm1 |
| Substrate | |
Cross database links:
| Pfam: | PF00168 PF00632 PF00397 |
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Gene Ontology
GO:0005737
C:cytoplasm
GO:0016881
F:acid-amino acid ligase activity
GO:0005515
F:protein binding
GO:0019871
F:sodium channel inhibitor activity
GO:0010766
P:negative regulation of sodium ion transport
GO:0006464
P:protein modification process
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References (12)[1] “A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.” Kamynina E.et.al. 11149908 [2] “The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels.” Fotia A.B.et.al. 12424229 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “The transcriptional landscape of the mammalian genome.” Carninci P.et.al. 16141072 [5] “Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression.” Debonneville C.et.al. 11742982 [6] “The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.” Harvey K.F.et.al. 11244092 [7] “Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.” Konstas A.-A.et.al. 12050153 [8] “Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.” Fotia A.B.et.al. 15123669 [9] “Participation of the ubiquitin-conjugating enzyme UBE2E3 in Nedd4-2-dependent regulation of the epithelial Na+ channel.” Debonneville C.et.al. 14993279 [10] “Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by nedd4-2 phosphorylation and increased na+ transport in cortical collecting duct cells.” Flores S.Y.et.al. 15958725 | |
| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MSLCEAPVHV GDKELKYFQI PQMLSQLSLL ASHHSRGLEF SGGQGESRIL RVKVVSGIDL 61: AKKDIFGASD PYVKLSLYVA DENRELALVQ TKTIKKTLNP KWNEEFYFRV NPSNHRLLFE 121: VFDENRLTRD DFLGQVDVPL SHLPTEDPTM ERPYTFKDFL LRPRSHKSRV KGFLRLKMAY 181: MPKNGGQDEE NSEQRDDMEH GWEVVDSNDS ASQHQEELPP PPLPPGWEEK VDNLGRTYYV 241: NHNNRSTQWH RPSLMDVSSE SDNNIRQINQ EAAHRRFRSR RHISEDLEPE ASEGGGEGPE 301: PWETISEEMN MAGDSLSLAL PPPPASPVSR TSPQELSEEV SRRLQITPDS NGEQFSSLIQ 361: REPSSRLRSC SVTDTVAEQA HLPPPSTPTR RARSSTVTGG EEPTPSVAYV HTTPGLPSGW 421: EERKDAKGRT YYVNHNNRTT TWTRPIMQLA EDGASGSATN SNNHLVEPQI RRPRSLSSPT 481: VTLSAPLEGA KDSPIRRAVK DTLSNPQSPQ PSPYNSPKPQ HKVTQSFLPP GWEMRIAPNG 541: RPFFIDHNTK TTTWEDPRLK FPVHMRSKAS LNPNDLGPLP PGWEERIHLD GRTFYIDHNS 601: KITQWEDPRL QNPAITGPAV PYSREFKQKY DYFRKKLKKP ADIPNRFEMK LHRNNIFEES 661: YRRIMSVKRP DVLKARLWIE FESEKGLDYG GVAREWFFLL SKEMFNPYYG LFEYSATDNY 721: TLQINPNSGL CNEDHLSYFT FIGRVAGLAV FHGKLLDGFF IRPFYKMMLG KQITLNDMES 781: VDSEYYNSLK WILENDPTEL DLMFCIDEEN FGQTYQVDLK PNGSEIMVTN ENKREYIDLV 841: IQWRFVNRVQ KQMNAFLEGF TELLPIDLIK IFDENELELL MCGLGDVDVN DWRQHSIYKN 901: GYCPNHPVIQ WFWKAVLLMD AEKRIRLLQF VTGTSRVPMN GFAELYGSNG PQLFTIEQWG 961: SPEKLPRAHT CFNRLDLPPY ETFEDLREKL LMAVENAQGF EGVD