1.A.155.1.2 Ferritin, light chain of 175 aas/heavy chain of 182 aas. It stores iron in a soluble, non-toxic, readily available form. Important
for iron homeostasis. Iron is taken up in the ferrous form and deposited
as ferric hydroxides after oxidation. It also plays a role in delivery of
iron to cells and mediates iron uptake in capsule cells of the developing
kidney. Delivery to lysosomes by the cargo receptor NCOA4 for autophagic degradation and release or iron has been documented.
|
Accession Number: | Q8MIP0 |
Protein Name: | Ferritin heavy chain |
Length: | 182 |
Molecular Weight: | 21269.00 |
Species: | Equus caballus (Horse) [9796] |
Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
Substrate |
iron atom |
---|
1: MTTAFPSQVR QNYHQDSEAA INRQINLELH ASYVYLSMSF YFDRDDVALK NFAKYFLHQS
61: HEEREHAEKL MKLQNQRGGR IFLQDIKKPD QDDWENGLKA MECALHLEKN VNESLLELHK
121: LATDKNDPHL CDFLETHYLN EQVKAIKELG DHVTNLRRMG APESGMAEYL FDKHTLGECD
181: ES