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2.A.6.2.22
The conjugated and unconjugated bile (bile-inducible)/multidrug (ethidium, ciprofloxacin, norfloxacin, tetracycline, cefotaxime, rifampicin, erythromycin, chloramphenicol, salicylate; drug-noninducible) efflux pump, CmeABC (Lin et al., 2005).  The 3-d structure of the OMF, CmeC, has been determined (Su et al. 2014). The system is involved in biofilm production (Teh et al. 2017).

Accession Number:Q8RTE3
Protein Name:CmeC
Length:492
Molecular Weight:55406.00
Species:Campylobacter jejuni [197]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate rifampicin, ciprofloxacin, norfloxacin, chloramphenicol, cefotaxime, tetracycline, erythromycin A, bile acid, ethidium, salicylate

Cross database links:

Pfam: PF02321   

Gene Ontology

GO:0016020 C:membrane
GO:0008289 F:lipid binding
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (2)

[1] “CmeABC functions as a multidrug efflux system in Campylobacter jejuni.”  Lin J.et.al.   12069964
[2] “CmeR functions as a transcriptional repressor for the multidrug efflux pump CmeABC in Campylobacter jejuni.”  Lin J.et.al.   15728904
Structure:
4MT4     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MNKIISISAI ASFTLLISAC SLSPNLNIPE ANYSIDNKLG ALSWEKETNS SITKNWWKDF 
61:	DDENLNKVVD LALKNNNDLK LAFIHMEQAA AQLGIDFSSL LPKFDGSASG SRAKTAINAP 
121:	SNRTGEVSYG NDFKMGLNLS YEIDLWGKYR DTYRASKSGF KASEYDYEAA RLSVISNTVQ 
181:	TYFNLVNAYE NENALKEAYE SAKEIYRIND EKFQVGAVGE YELAQARANL ESMALQYNEA 
241:	KLNKENYLKA LKILTSNDLN DILYKNQSYQ VFNLKEFDIP TGISSTILLQ RPDIGSSLEK 
301:	LTQQNYLVGV ARTAFLPSLS LTGLLGFESG DLDTLVKGGS KTWNIGGNFT LPIFHWGEIY 
361:	QNVNLAKLNK DEAFVNYQNT LITAFGEIRY ALVARKTIRL QYDNAQASEQ SYKRIYEIAK 
421:	ERYDIGEMSL QDYLEARQNW LNAAVAFNNI KYSYANSIVD VIKAFGGGFE QSEDTSKNIK 
481:	EESKNLDMSF RE