2.A.6.2.22
The conjugated and unconjugated bile (bile-inducible)/multidrug (ethidium, ciprofloxacin, norfloxacin, tetracycline, cefotaxime, rifampicin, erythromycin, chloramphenicol, salicylate; drug-noninducible) efflux pump, CmeABC (Lin et al., 2005). The 3-d structure of the OMF, CmeC, has been determined (Su et al. 2014). The system is involved in biofilm production (Teh et al. 2017).
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| Accession Number: | Q8RTE4 |
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| Protein Name: | CmeB |
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| Length: | 1040 |
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| Molecular Weight: | 113963.00 |
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| Species: | Campylobacter jejuni [197] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
rifampicin, ciprofloxacin, norfloxacin, chloramphenicol, cefotaxime, tetracycline, erythromycin A, bile acid, ethidium, salicylate |
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| RefSeq: |
YP_001000077.1
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| Entrez Gene ID: |
4682137
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| Pfam: |
PF00873
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[1] “CmeABC functions as a multidrug efflux system in Campylobacter jejuni.” Lin J. et.al. 12069964
[2] “CmeR functions as a transcriptional repressor for the multidrug efflux pump CmeABC in Campylobacter jejuni.” Lin J. et.al. 15728904
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1: MFSKFFIERP VFASVVAIII SLAGAIGLTN LPIEQYPSLT PPTVKVSATY TGADAQTIAS
61: TVASPIEDAI NGADNMIYMD STSSSSGTMS LTVYFDIGTD PDQATIDVNN RISAATAKMP
121: DAVKKLGVTV RKTSSTTLAA ISMYSSDGSM SAVDVYNYIT LNVLDELKRV PGVGDANAIG
181: NRNYSLRIWL KPDLLNKFGI TATDVISAVN DQNAQYATGK IGEEPVTQKS PYVYSITMQG
241: RLQNPSEFEN IILRTNNDGS FLRLKDVADV EIGSQQYSSQ GRLNGNDAVP IMINLQSGAN
301: ALHTAELVQA KMQELSKNFP KGLTYKIPYD TTKFVIESIK EVVKTFVEAL ILVIIVMYMF
361: LKNFRATLIP MIAVPVSLLG TFAGLYVLGF SINLLTLFAL ILAIGIVVDD AIIVVENIDR
421: ILHENEQISV KDAAIQAMQE VSSPVISIVL VLCAVFVPVS FISGFVGEIQ RQFALTLAIS
481: VTISGFVALT LTPSLCALFL RRNEGEPFKF VKKFNDFFDW STSVFSAGVA YILKRTIRFV
541: LIFCIMLGAI FYLYKAVPNS LVPEEDQGLM ISIINLPSAS ALHRTISEVD HISQEVLKTN
601: GVKDAMAMIG FDLFTSSLKE NAAAMFIGLQ DWKDRNVSAD QIIAELNKKF AFDRNASSVF
661: IGLPPIPGLS ITGGFEMYVQ NKSGKSYDEI QKDVNKLVAA ANQRKELSRV RTTLDTTFPQ
721: YKLIIDRDKL KHYNLNMQDV FNTMNATIGT YYVNDFSMLG KNFQVNIRAK GDFRNTQDAL
781: KNIFVRSNDG KMIPLDSFLT LQRSSGPDDV KRFNLFPAAQ VQGQPAPGYT SGQAIEAIAQ
841: VAKETLGDDY SIAWSGSAYQ EVSSKGTASY AFALGMIFVF LILAAQYERW LIPLAVVTAV
901: PFAVFGSFLL VYLRGFSNDI YFQTGLLLLI GLSAKNAILI VEFAMEERFK KGKGVFEAAV
961: AAAKLRFRPI IMTSLAFTFG VLPMIFATGA GSASRHSLGT GLIGGMIAAS TLAIFFVPLF
1021: FYLLENFNEW LDKKRGKVHE