2.A.6.2.22
The conjugated and unconjugated bile (bile-inducible)/multidrug (ethidium, ciprofloxacin, norfloxacin, tetracycline, cefotaxime, rifampicin, erythromycin, chloramphenicol, salicylate; drug-noninducible) efflux pump, CmeABC (Lin et al., 2005). The 3-d structure of the OMF, CmeC, has been determined (Su et al. 2014). The system is involved in biofilm production (Teh et al. 2017).
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| Accession Number: | Q8RTE5 |
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| Protein Name: | CmeA |
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| Length: | 367 |
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| Molecular Weight: | 40005.00 |
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| Species: | Campylobacter jejuni [197] |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
rifampicin, ciprofloxacin, norfloxacin, chloramphenicol, cefotaxime, tetracycline, erythromycin A, bile acid, ethidium, salicylate |
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| RefSeq: |
YP_001000078.1
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| Entrez Gene ID: |
4683757
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| Pfam: |
PF00529
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[1] “CmeABC functions as a multidrug efflux system in Campylobacter jejuni.” Lin J. et.al. 12069964
[2] “CmeR functions as a transcriptional repressor for the multidrug efflux pump CmeABC in Campylobacter jejuni.” Lin J. et.al. 15728904
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1: MKLFQKNTIL ALGVVLLLAA CSKEEAPKIQ MPPQPVTTMS AKSEDLPLSF TYPAKLVSDY
61: DVIIKPQVSG VIVNKLFKAG DKVKKGQTLF IIEQDKFKAS VDSAYGQALM AKATFENASK
121: DFNRSKALFS KSAISQKEYD SSLATFNNSK ASLASARAQL ANARIDLDHT EIKAPFDGTI
181: GDALVNIGDY VSASTTELVR VTNLNPIYAD FFISDTDKLN LVRNTQSGKW DLDSIHANLN
241: LNGETVQGKL YFIDSVIDAN SGTVKAKAVF DNNNSTLLPG AFATITSEGF IQKNGFKVPQ
301: IGVKQDQNDV YVLLVKNGKV EKSSVHISYQ NNEYAIIDKG LQNGDKIILD NFKKIQVGSE
361: VKEIGAQ