3.D.4.11.1
Cytochrome oxidase (Cox or CcO). Reversible hydration-level changes of the cavity can be a key factor that regulates the branching of proton transfer events and therefore contributes to the vectorial efficiency of proton transport (Son et al. 2017). Cox16 is required for the assembly of the mitochondrial cytochrome c oxidase (respiratory chain complex IV (CIV)), possibly by promoting the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (Cerqua et al. 2018; Aich et al. 2018). Lipid composition affects the efficiency of the functional reconstitution of the cytochrome c oxidase (Hugentobler et al. 2020). The DeepCys program has been used to predict the functions of cysteine residues in Cox2 (Nallapareddy et al. 2021).
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| Accession Number: | Q8TF08 |
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| Protein Name: | CoxVIIb2 |
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| Length: | 81 |
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| Molecular Weight: | 9077.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Mitochondrion inner membrane1 |
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| Substrate |
hydron |
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| RefSeq: |
NP_570972.2
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| Entrez Gene ID: |
170712
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| Pfam: |
PF05392
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| OMIM: |
609811 gene
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| KEGG: |
hsa:170712
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[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team et.al. 15489334
[2] “A rare polymorphism of the COX7B2 gene in a Cantonese family with nasopharyngeal carcinoma.” Liang H. et.al. 15623157
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