TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.56.1.11
Tripartite high affinity ectoine/hydroxyectoine uptake system (Grammann et al., 2002). Deletion leads to increased rates of ectoine excretion (Hobmeier et al. 2022). In the absence of the substrate-binding protein, TeaA, an overexpression of both subunits TeaBC facilitated a three-fold increased excretion rate of ectoine export. Individually, the large subunit TeaC showed an approximately five times higher extracellular ectoine concentration per dry weight compared to TeaBC shortly after its expression was induced. This led to the possibility that only the large subunit, TeaC, is required for channel function (Hobmeier et al. 2022).

Accession Number:Q8VPB2
Protein Name:TeaB
Length:193
Molecular Weight:21478.00
Species:Halomonas elongata [2746]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Pfam: PF04290   

Gene Ontology

GO:0016021 C:integral to membrane

References (1)

[1] “New type of osmoregulated solute transporter identified in halophilic members of the bacteria domain: TRAP transporter TeaABC mediates uptake of ectoine and hydroxyectoine in Halomonas elongata DSM 2581(T).”  Grammann K.et.al.   12003950

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MTDEEEAEKH YHSGLPGILG TIDTLISKLE AIILALGVLL MATNTVANVI GRFALGESLF 
61:	FTGEVNRILI IMITFAGIGY AARHGRHIRM SAIYDALPVG GRRALMIVIS LFTSLVMFFL 
121:	MYYSVHYVLD LYDKGRILPA LGFPIFIIYV WVPLGFLITG IQYLFTAIKN LTSRDVYLST 
181:	SVVDGYKDTE TEV