2.A.56.1.11 Tripartite high affinity ectoine/hydroxyectoine uptake system (Grammann et al., 2002). Deletion leads to increased rates of ectoine excretion (Hobmeier et al. 2022). In the absence of the substrate-binding protein, TeaA, an overexpression of both subunits TeaBC facilitated a three-fold increased excretion rate of ectoine export. Individually, the large subunit TeaC showed an approximately five times higher extracellular ectoine concentration per dry weight compared to TeaBC shortly after its expression was induced. This led to the possibility that only the large subunit, TeaC, is required for channel function (Hobmeier et al. 2022).
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Accession Number: | Q8VPB2 |
Protein Name: | TeaB |
Length: | 193 |
Molecular Weight: | 21478.00 |
Species: | Halomonas elongata [2746] |
Number of TMSs: | 4 |
Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
Substrate |
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Pfam: |
PF04290
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[1] “New type of osmoregulated solute transporter identified in halophilic members of the bacteria domain: TRAP transporter TeaABC mediates uptake of ectoine and hydroxyectoine in Halomonas elongata DSM 2581(T).” Grammann K. et.al. 12003950
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1: MTDEEEAEKH YHSGLPGILG TIDTLISKLE AIILALGVLL MATNTVANVI GRFALGESLF
61: FTGEVNRILI IMITFAGIGY AARHGRHIRM SAIYDALPVG GRRALMIVIS LFTSLVMFFL
121: MYYSVHYVLD LYDKGRILPA LGFPIFIIYV WVPLGFLITG IQYLFTAIKN LTSRDVYLST
181: SVVDGYKDTE TEV