2.A.82.1.1
The organic solute transporter, OSTα/OSTβ, which transports steroids and other organic solutes including taurocholate, estrone sulfate, digoxin, and prostaglandin E2 (Wang et al. 2001). Transport is sodium-independent, saturable, and inhibited by other steroids and anionic drugs. Human and mouse OSTalpha-OSTbeta were able to mediate transport of taurocholate, digoxin, and
prostaglandin E2 but not of estradiol 17beta-d-glucuronide or
p-aminohippurate (Seward et al. 2003).
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| Accession Number: | Q90YM4 |
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| Protein Name: | OST beta |
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| Length: | 182 |
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| Molecular Weight: | 20343.00 |
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| Species: | Raja erinacea (Little skate) [7782] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
taurocholic acid, prostaglandin E2, estrone 3-sulfate, digoxin |
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[1] “Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate.” Wang W. et.al. 11470901
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1: MSGLLKYLFG CFILCLLLQG KTHMTSATIS KPHETIDIEK QNMTGERNST LAQQLSFPME
61: DPTNWNYAIL ALAFVVLFLA FLILAQNSRA NRTRKMKALN GAGGRNETEA DSTQKAMMQY
121: VVEVDNLAET DQMLQSKPTY ISLNQVAQTS SPKVLPKEGQ ILVEWKDGNI GFLYTDSKED
181: DV