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2.A.82.1.1
The organic solute transporter, OSTα/OSTβ, which transports steroids and other organic solutes including taurocholate, estrone sulfate, digoxin, and prostaglandin E2 (Wang et al. 2001). Transport is sodium-independent, saturable, and inhibited by other steroids and anionic drugs. Human and mouse OSTalpha-OSTbeta were able to mediate transport of taurocholate, digoxin, and prostaglandin E2 but not of estradiol 17beta-d-glucuronide or p-aminohippurate (Seward et al. 2003).

Accession Number:Q90YM5
Protein Name:OST alpha
Length:352
Molecular Weight:39345.00
Species:Raja erinacea (Little skate) [7782]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate taurocholic acid, prostaglandin E2, estrone 3-sulfate, digoxin

Cross database links:

Pfam: PF03619   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate.”  Wang W.et.al.   11470901

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MDVAHPEEVT RFSPDILMEK FNVSEACFLP PPISIQLILQ LTWLDIGVFA ALTAMTVLTI 
61:	AIYLEIVCYL MDKVKCPIKR KTLMWNSAAP TVIAITSCLG LWVPRAIMFV DMAAAMYFGV 
121:	GFYLMLLIIV QGYGGEEAML QHLATHTIRI STGPCCCCCP CLPHIHLTRQ KYKIFVLGAF 
181:	QVAFLRPALF LLGVVLWTNG LYDPDDWSST SIFLWLNLFL GVSTILGLWP VNVLFRHSKV 
241:	LMADQKLTCK FALFQAILIL SSLQNSIIGT LAGAGHIGCA PPYSARTRGQ QMNNQLLIIE 
301:	MFFVGILTRI SYRKRDDRPG HRHVGEVQQI VRECDQPAIA DQQADHSSIS HI