9.A.63.1.1
The yeast retromer-dependent Vacuolar Protein Sorting (VPS) apparatus (Feyder et al. 2015). The sorting nexin (SNX) proteins, homologous to retromer-dependent VPS protein, Q92331, that normally function in endosomal membrane trafficking, are a major class of inclusion-associated host proteins in chlamydial infection (Paul et al. 2017). Some of the components of this system are homologous to those of the retromer complexes in animals (see 9.A.3; McNally and Cullen 2018). VPS1, a GTPase involved in membrane fusion/fission, of 704 aas, may be involved in Coenzyme Q uptake and trafficking (Guile et al. 2023). The dynamin-like GTPase Vps1 mediates Atg9 transport to the phagophore assembly site (Hu and Reggiori 2023). The yeast dynamin-like GTPase Vps1 mediates Atg9 transport to the phagophore assembly site in Saccharomyces cerevisiae (Hu and Reggiori 2023).
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| Accession Number: | Q92331 |
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| Protein Name: | Vacuolar protein sorting-associated protein 5 |
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| Length: | 675 |
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| Molecular Weight: | 76484.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
protein polypeptide chain |
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1: MDYEDNLEAP VWDELNHEGD KTQSLVSNSI ESIGQISTNE ERKDNELLET TASFADKIDL
61: DSAPEWKDPG LSVAGNPQLE EHDNSKADDL INSLAPEQDP IADLKNSTTQ FIATRESGGA
121: LFTGNANSPL VFDDTIYDAN TSPNTSKSIS GRRSGKPRIL FDSARAQRNS KRNHSLKAKR
181: TTASDDTIKT PFTDPLKKAE KENEFVEEPL DDRNERRENN EGKFTASVEK NILEQVDRPL
241: YNLPQTGANI SSPAEVEENS EKFGKTKIGS KVPPTEKAVA FKVEVKDPVK VGELTSIHVE
301: YTVISESSLL ELKYAQVSRR YRDFRWLYRQ LQNNHWGKVI PPPPEKQSVG SFKENFIENR
361: RFQMESMLKK ICQDPVLQKD KDFLLFLTSD DFSSESKKRA FLTGSGAIND SNDLSEVRIS
421: EIQLLGAEDA AEVLKNGGID AESHKGFMSI SFSSLPKYNE ADEFFIEKKQ KIDELEDNLK
481: KLSKSLEMVD TSRNTLAAST EEFSSMVETL ASLNVSEPNS ELLNNFADVH KSIKSSLERS
541: SLQETLTMGV MLDDYIRSLA SVKAIFNQRS KLGYFLVVIE NDMNKKHSQL GKLGQNIHSE
601: KFREMRKEFQ TLERRYNLTK KQWQAVGDKI KDEFQGFSTD KIREFRNGME ISLEAAIESQ
661: KECIELWETF YQTNL